摘要
目的研究艳山姜Alpinia zerumbet(Pers.) Burtt.et Smith叶的化学成分。方法艳山姜叶95%乙醇提取物采用硅胶、Sephadex LH-20、MCI及HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到10个化合物,分别鉴定为caryophyllene oxide(1)、α-tocopherol(2)、cassipourol(3)、2′,3′-dihydroxy propylpentadecanoate(4)、trans-cinnamic acid(5)、indole-3-aldehyde(6)、5,7-methoxyflavanone(7)、alpinetin(8)、dihydroflavokawin B(9)、2′-hydroxy-4′,6′-dimethoxychalcone(10)。结论化合物1~7为首次从该植物中分离得到。
AIM To study the chemical constituents from the leaves of Alpinia zerumbet(Pers.) Burtt.et Smith.METHODS The 95% ethyl acetate extract from the leaves of A. zerumbet was isolated and purified by silica, Sephadex LH-20, MCI and HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Ten compounds were isolated and identified as caryophyllene oxide(1), α-tocopherol(2), cassipourol(3), 2′,3′-dihydroxy propylpentadecanoate(4), trans-cinnamic acid(5), indole-3-aldehyde(6), 5,7-methoxyflavanone(7),alpinetin(8),dihydroflavokawin B(9), 2′-hydroxy-4′,6′-dimethoxychalcone(10).CONCLUSION Compounds 1-7 are isolated from this plant for the first time.
作者
游华林
周芹茹
吴林菁
廖尚高
沈祥春
张嫩玲
YOU Hua-lin;ZHOU Qin-ru;WU Lin-jing;LIAO Shang-gao;SHEN Xiang-chun;ZHANG Nen-ling(College of Pharmacy,Guizhou Medical University,Guiyang 550025,China;Engineering Center for Efficient Utilization of Natural Medicinal Resources/High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Drug Druggability/Key Laboratory for Optimal Utilization of Natural Medicinal Resources,Guiyang 550025,China)
出处
《中成药》
CAS
CSCD
北大核心
2022年第1期114-117,共4页
Chinese Traditional Patent Medicine
基金
国家自然科学基金资助项目(81860612,U1812403-4-4)
贵州省科技厅科技支撑计划项目(黔科合支撑[2018]2767)
贵阳市科技局-贵州医科大学联合基金(筑科合同[2017]30-37)
贵州省高层次创新型人才百层次人才项目(贵州省科技厅黔科合人才[2015]4029)
贵州医科大学药学国际科技合作基地(黔科合平台人才[2017]5802)
贵州省教育厅青年科技人才成长项目(黔教合KY字[2018]200)。
关键词
艳山姜
叶
化学成分
分离鉴定
Alpinia zerumbet(Pers.)Burtt.et Smith
leaves
chemical constituents
isolation and identification
