摘要
目的 对翅果油树(Elaeagnus mollis Diels)叶的化学成分进行研究。方法 利用硅胶柱色谱、Sephadex LH-20柱色谱和制备高效液相色谱等手段进行分离纯化,根据理化性质和波谱数据对化合物进行结构鉴定。结果 从翅果油树叶体积分数70%的乙醇提取物中分离得到16个化合物,分别鉴定为正二十八烷醇(1)、正二十六烷醇(2)、硬脂酸甘油酯(3)、十七烷酸(4)、β-谷甾醇(5)、(2S,3S,4R,8E)-2-[(2′R)-2-羟基二十三酰胺]-8-十八碳烯-1, 3, 4-三醇(6)、亚麻酸甲酯(7)、4-羟基苯甲酸甲酯(8)、香草酸(9)、对羟基苯甲醛(10)、nectandrin B(11)、落叶松树脂醇(12)、(-)-地芰普内酯(13)、新海胆灵A(14)、苏式-3,3′-二甲氧基-4-O-8′-新木脂素-9,4′,7′,9′-四醇-7(8)-烯(15)、(7S,8R)-脱氢双松柏醇-9′-β-D-葡萄糖苷(16)。结论 化合物6、7、11~16均为首次从胡颓子属植物中分离得到。
In order to carry out the chemical constituents of the 70%(V/V)ethanol extracts from leaves of Elaeagnus mollis Diels,various isolation methods,such as silica gel,ODS,Sephadex LH?20 column chromatography and HPLC were adopted.Sixteen compounds were isolated and purified.The structures were identified by measuring the physicochemical property and spectral data,which were octacosanol(1),1?hexacosanol(2),glycerin monostearate(3),heptadecanoic acid(4),β?sitosterol(5),(2S,3S,4R,8E)?2?[(2′R)?2?hydroxy?tricosanoylamino]?8?octadecene?1,3,4?triol(6),methyl linolenate(7),methyl 4?hydroxybenzoate(8),vanillic acid(9),p?hydroxybenzaldehyde(10),nectandrin B(11),(+)?lariciresinol(12),(-)?loliolide(13),neoechinulin A(14),threo?3,3′?dimethoxy?4?O?8′?oxyneoligna?9,4′,7′,9′?tetraol?7(8)?ene(15)and(7S,8R)?dehydrodiconiferyl alcohol?9′?β?D?glucopyranoside(16).Compounds 6,7,11-16 were isolated from Elaeagnus fQq408genus for the first time.
作者
李乔
于洋
李娟
郭坤
赵玉丹
路金才
吕重宁
LI Qiao;YU Yang;LI Juan;GUO Kun;ZHAO Yu?dan;LU Jin?cai;LU Chong?ning(The First Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China;Shanxi Qierkang Chiguo Biological Product Co.,Ltd.,Linfen 042100,China)
出处
《中国药物化学杂志》
CAS
CSCD
北大核心
2020年第1期39-44,共6页
Chinese Journal of Medicinal Chemistry
基金
辽宁省新选派省级科技特派团项目(2018103025)
辽宁省中药资源普查项目(2018016,2018018)
沈阳药科大学中青年教师事业发展支持计划项目(ZQN2018013).
关键词
翅果油树
化学成分
分离
结构鉴定
Elaeagnus mollis Diels
chemical constituent
isolation
structural identification
