摘要
目的探讨2016-2019年贵阳市哨点吸毒人群人类免疫缺陷病毒(HIV)、苍白梅毒螺旋体(TP)和丙型肝炎病毒(HCV)感染情况及影响因素。方法选择2016-2019年参加贵阳市艾滋病哨点监测并已采血进行HIV、梅毒、HCV检测的吸毒人员1585例作为研究对象,通过电子病历调查和设计调查问卷的方式收集患者资料,包括一般人口学信息、艾滋病防治有关信息、行为学信息及HIV、梅毒、HCV抗体检测结果情况,分析HIV、梅毒、HCV感染特点及其影响因素。结果HIV、梅毒和HCV总体阳性率分别为1.01%(16/1585)、15.33%(243/1585)和46.50%(737/1585);单因素分析结果显示,HIV阳性与性别有关(P<0.05),梅毒阳性与性别、文化程度、注射毒品有关(P<0.05),HCV阳性与性别、年龄、文化程度低、HIV知晓情况、近一年接受社区维持治疗/清洁针具提供/交换、注射毒品、吸食海洛因、公用针具有关(P<0.05);多因素Logistic回归分析结果显示:性别、文化程度低、注射毒品是导致吸毒人群梅毒感染的影响因素(P<0.05),年龄较大、注射毒品、公用针具是吸毒人群HCV感染的影响因素(P<0.05),未发现HIV感染的影响因素。结论贵阳市吸毒人群HIV感染阳性率低于其他哨点监测结果,但HCV和梅毒感染率均较同期其他哨点较高,应注意针对其临床因素进行针对性预防。
OBJECTIVE To investigate the infection status and influencing factors of human immunodeficiency virus(HIV),treponema pallidum(TP)and hepatitis C virus(HCV)among sentinel drug users in Guiyang from 2016 to 2019.METHODS From 2016to 2019,1585drug addicts who participated in the Guiyang sentinel surveillance and whose blood were sampled for HIV,syphilis,and HCV testing were selected as research subjects.Patient data were collected through electronic medical record surveys and questionnaire design,including general demographic information,AIDS prevention and treatment information,behavioral information and HIV,syphilis,HCV antibody test results,and the characteristics and influencing factors of HIV,syphilis,HCV infection was analyzed.RESULTS The overall positive rates of HIV,syphilis and HCV were 1.01%(16/1585),15.33%(243/1585),and 46.50%(737/1585),respectively.The results of univariate analysis showed that HIV positive was related to gender(P<0.05),syphilis positive was related to gender,education level,and injecting drugs(P<0.05),HCV positive was related to gender,age,low education level,HIV awareness,receiving community maintenance treatment/cleaning needles and supplies/exchange,injection of drugs in the past year,Heroin use,and public needles were related(P<0.05).Multivariate logistic regression analysis results showed that gender,low education level,and injecting drugs were the influencing factors of syphilis infection in drug users(P<0.05),older age,injection of drugs and public needles were the influencing factors of HCV infection among drug users(P<0.05),and no influencing factors of HIV infection were found.CONCLUSIONThe HIV positive rate of drug users in Guiyang was lower than other sentinel surveillance results,while the infection rates of HCV and syphilis were higher than those of other sentinel surveillance sites in the same period.Therefore,more attention should be paid to the clinical factors for targeted prevention.
作者
姚佐薇
周健
朱焱
袁飞
佘敏
李劲
YAO Zuo-wei;ZHOU Jian;ZHU Yan;YUAN Fei;SHE Min;LI Jin(Guizhou Medical University,Guiyang,Guizhou 550025,China;不详)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2021年第19期3003-3007,共5页
Chinese Journal of Nosocomiology
基金
贵州省教育厅高等学校人文社会科学研究基金资助项目(2018gh07)。
