摘要
目的通过对HIV抗体筛查有反应标本的复核及确证试验,探讨其对早发现、早诊断艾滋病感染者的影响。方法对2018—2020年宣城市辖区所有艾滋病筛查有反应的血清标本进行复核、确证和补充试验,分析HIV抗体检测复核与确证结果,了解HIV感染状况。结果 2018—2020年宣城市共发现556份筛查有反应标本,复核有反应540份,一致率为97.12%。首次确证试验HIV抗体阳性的413份,占74.28%,413份HIV-1抗体确认阳性标本中,gp160条带和p24条带分别为100%和99.74%;首次确证试验结果为不确定的53份标本,占9.53%,gp160条带出现频率最高,占45.28%。对40例HIV抗体不确定者进行追踪随访,发现HIV抗体阳性28例。结论艾滋病筛查有反应标本需进行复核、确证试验,对确证试验结果为不确定人群需进行随访和核酸检测补充试验,确保潜在HIV感染者的及时、精准诊断。
Objective Through the review and confirmatory test of specimens that were responsive to HIV antibody screening,its impact on early detection and early diagnosis of HIV infection was discussed.Method All serum specimens that were responsive to HIV screening in Xuancheng City from 2018 to 2020 were rechecked,confirmed and supplemented.The re-examination and confirmation results of HIV antibody test were analyzed to confirm the HIV infection status.Results From 2018 to 2020,a total of 556 specimens that were responsive to HIV antibody screening were found in Xuancheng City,and 540 samples were found to be responsive in the re-examination testing,with a consistency rate of 97.12%.In the first confirmatory test,there were 413 HIV antibody positive specimens,accounting for 74.28%.Among 413 HIV-1 antibody positive specimens,gp160 and p24 band were 100%and 99.74%respectively.53 specimens were confirmed as uncertain in the first confirmatory test,accounting for 9.53%.The results of the first confirmatory test were 53 uncertain specimens,accounting for 9.53%,and the frequency of gp160 band was the highest,accounting for 45.28%.40 patients with uncertain HIV antibody were followed up,and 28 cases were found to be HIV antibody positive.Conclusion In order to ensure timely and accurate diagnosis of potential AIDS infected people,the specimens that responsive to HIV screening need to be reviewed and re-confirmed,follow-up and supplementary nucleic acid testing tests should be conducted for people with uncertain confirmatory test results.
作者
王敏
陈晓龙
艾平
黄志伟
WANG Min;CHEN Xiao-long;AI Ping;HUANG Zhi-wei(Xuancheng Center for Disease Control and Prevention,Anhui 242000,China)
出处
《安徽预防医学杂志》
2021年第5期363-365,共3页
Anhui Journal of Preventive Medicine
