摘要
目的:研究青蒿扶正解毒汤治疗系统性红斑狼疮(SLE)的临床疗效。方法:选取2019年12月至2020年10月武汉市第一医院风湿免疫科收治的109例SLE患者为研究对象,采用随机数字表法分为观察组(55例)和对照组(54例),其中观察组脱落2例,合计53例,对照组脱落1例,合计53例,对照组给予泼尼松片和硫唑嘌呤治疗,观察组患者在对照组基础上加用青蒿扶正解毒汤治疗,比较两组临床疗效、中医证候积分、中医证候疗效、免疫球蛋白(Ig)G,IgA,IgM及补体C3,C4变化情况,统计两组患者治疗后抗核抗体(ANA)及抗双链脱氧核糖核酸抗体(ds-DNA)转阴情况。结果:观察组临床治疗总有效率(92.45%)明显高于对照组总有效率(73.58%),差异有统计学意义(χ^(2)=6.692,P<0.05)。治疗前,两组IgG,IgA,IgM及补体C3,C4水平,血清ANA,ds-DNA滴度比较差异无统计学意义;治疗后,两组IgG,IgA,IgM水平,血清ANA,ds-DNA滴度与治疗前比较明显下降,补体C3,C4水平明显上升(P<0.05),与对照组比较,观察组患者IgG,IgA,IgM水平,血清ANA,ds-DNA滴度明显降低,补体C3,C4水平明显上升(P<0.05),观察组ANA,ds-DNA转阴率明显高于对照组(χ^(2)=8.040,P<0.05)。与治疗前比较,两组中医证候积分均明显下降,且对照组中医证候积分明显高于观察组(P<0.05);观察组中医证候疗效总有效率(94.34%)明显高于对照组中医证候治疗总有效率(50.94%),差异有统计学意义(χ^(2)=25.112,P<0.05)。结论:青蒿扶正解毒汤治疗SLE疗效确切,具有一定临床应用价值。
Objective:To study the clinical effect of Qinghao Fuzheng Jiedu decoction on systemic lupus erythematous(SLE).Method:A total of 109 SLE patients admitted to the Rheumatology and Immunology Department of Wuhan No.1 Hospital from December 2019 to October 2020 were selected and divided into an observation group(55 cases)and a control group(54 cases)using the random number table.Two cases in the observation group dropped out,leaving a total sample of 53,and one case in the control group dropped out,with 53 cases finally included.Patients in the control group were treated with prednisone tablet and azathioprine.On this basis,those in the observation group further received Qinghao Fuzheng Jiedu decoction.The clinical efficacy,traditional Chinese medicine(TCM)syndrome score,TCM syndrome efficacy,immunoglobulin(Ig)G,IgA,IgM,and complements C3 and C4 of the two groups were compared.The conversion of positive antinuclear antibody(ANA)and anti-double-stranded deoxyribonucleic acid antibody(DS-DNA)titers to negative in two groups after treatment was analyzed.Result:The total clinical efficacy rate of the observation group was significantly higher than that of control group(92.45%vs 73.58%,χ^(2)=6.692,P<0.05).Before treatment,there were no significant differences in IgG,IgA,IgM,complements C3 and C4,and serum ANA and ds-DNA titers between two groups.After treatment,the levels of IgG,IgA,and IgM and serum ANA and ds-DNA titers in both groups obviously declined,whereas the levels of complements C3 and C4 rose(P<0.05).Besides,the levels of IgG,IgA,and IgM and serum ANA and ds-DNA titers in the observation group were lower than those in the control group,while the levels of complements C3 and C4 were higher(P<0.05).The negative rates of ANA and ds-DNA in observation group were significantly higher than those in control group(χ^(2)=8.040,P<0.05).TCM syndrome scores were decreased in both groups after treatment(P<0.05),and the score in observation group was lower than that in control group(P<0.05).In terms of TCM syndrome efficacy,the total effective rate of observation group was significantly increased as compared with that of the control group(94.34%vs 50.94%,χ^(2)=25.112,P<0.05).Conclusion:Qinghao Fuzheng Jiedu decoction is effective in treating SLE and has a certain clinical application value.
作者
何浩
杨惠琴
邹荣
HE Hao;YANG Hui-qin;ZOU Rong(Wuhan First Hospital,Wuhan 430000,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第21期138-143,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81600530)。
关键词
系统性红斑狼疮
青蒿扶正解毒汤
临床疗效
中医证候积分
免疫球蛋白
systemic lupus erythematous(SLE)
Qinghao Fuzheng Jiedu decoction
clinical efficacy
traditional Chinese medicine(TCM)syndrome score
immunoglobulin
