摘要
系统性红斑狼疮是一种以免疫细胞功能紊乱和自身抗体产生为基础的、多系统受累的自身免疫性疾病。系统性红斑狼疮的发病机制复杂且尚未明确,最近研究表明,哺乳动物雷帕霉素靶蛋白(mTOR)作为一种丝氨酸/苏氨酸蛋白激酶,在调控免疫细胞分化、自噬、炎性因子分泌及氧化应激过程中起至关重要的作用,这与狼疮发病密切相关。大量研究表明,阻断mTOR有助于狼疮患者病情的控制。为了更深入地了解mTOR信号通路与狼疮发病的关系以及抑制该通路治疗系统性红斑狼疮的效果,本文就近年来关于mTOR信号通路在狼疮中的研究进展进行了综述,希望为狼疮的靶向治疗提供新策略。
Systemic lupus erythematosus(SLE)is a multi-system disease with underlying immune cell dysfunction and producing of autoantibodies.Although the etiology of SLE is only partly known,recent studies have found that mammalian target of rapamycin was a ubiquitous serine/threonine kinase,which played pivotal roles in regulating differentiation of immune cells,autophagy,cytokines excretion and oxidative stress and contributed to the pathogenesis of SLE as well.In this article,we review what is currently known in the role of mTOR signaling in SLE,and the investigations aimed at possibilities of mTOR-targeted therapeutic intervention in the disease.
作者
何晶晶
马隽
任柄睿
刘爱京(指导)
HE Jing-Jing;MA Jun;REN Bing-Rui;LIU Ai-Jing(Department of Rheumatology and Immunology,the Second Hospital of Hebei Medical Unversity,Shijiazhuang 050000,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2019年第22期2801-2805,共5页
Chinese Journal of Immunology
