摘要
目的探讨哮喘合并肺炎支原体(MP)感染患儿外周血中炎性因子的动态变化特点与患者预后的关系。方法将54例合并MP感染者哮喘患儿作为观察组,51例单纯哮喘患儿作为对照组,均给予哮喘常规治疗1~2周,观察组同时给予抗MP治疗4周;分别于治疗前及治疗1周、2周、4周时,检测2组患儿外周血白细胞介素-5(IL-5)、IL-8、肿瘤坏死因子-α(TNF-α)、单核细胞趋化蛋白-4(MCP-4)及半胱氨酰白三烯(CysLTs)水平;治疗后随访1年,记录2组患儿哮喘急性发作次数、平均住院次数及住院时间,合并MP感染者在治疗结束后行支原体抗体(MP-IgM)检查确定MP-IgM转阴率,采用Pearson相关分析观察组患儿外周血IL-5、IL-8、TNF-α、MCP-4、CysLTs与患儿哮喘急性发作次数、平均住院次数、平均住院时间及MP-IgM转阴率的相关性。结果观察组患儿治疗前、治疗1周、2周及4周后的血清IL-5、IL-8、TNF-α、MCP-4及CysLTs水平高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后MP-IgM转阴率85.19%,且其哮喘急性发作次数、平均住院次数多于对照组,住院时间长于对照组(P<0.05);观察组上述血清炎性因子水平与哮喘急性发作次数、平均住院次数、平均住院时间呈显著正相关(P<0.05),与MP-IgM转阴率呈负相关(P<0.05)。结论哮喘合并MP感染患儿经治疗后血清炎性因子水平明显降低,降低幅度越大则预后越好。
Objective To investigate the dynamic changes of peripheral blood inflammatory factors of children patients with asthma complicated with Mycoplasma pneumoniae(MP)infection and their correlation with prognosis.Methods Fifty-four children with asthma complicated with MP infection were selected in observation group,while 51 children with asthma without MP infection were included in control group.All patients were given routine asthma treatment for 1 to 2 weeks,and observation group was given anti-MP therapy for 4 weeks at the same time.Peripheral blood interleukin-5(IL-5),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),monocyte chemotactic protein-4(MCP-4),and cysteinyl leukotrienes(CysLTs)were measured before treatment,at 1 week,2 weeks,and 4 weeks of the treatment.One-year follow up was performed after treatment,recording the frequency of acute asthma attacks,average frequency of hospitalization and average hospital stay.MP antibody(MP-IgM)examination was performed on patients with MP infection to determine MP negative rate after the end of treatment.Pearson correlation analysis was used to analyze the association of peripheral blood IL-5,IL-8,TNF-α,MCP-4,and CysLTs with the number of acute asthma attacks,the average number of hospitalizations,the average length of stay and MP-IgM negative rate in observation group.Results The levels of serum IL-5,IL-8,TNF-α,MCP-4,and CysLTs before treatment,at 1 week,2 weeks and 4 weeks after treatment in observation group were higher than those in control group(P<0.05).The MP-IgM negative rate of children in observation group was 85.19%after treatment,and the number of acute asthma attacks,the average number of hospitalizations and hospital stay were greater in observation group than those of control group(P<0.05).In observation group,the levels of the above-mentioned inflammatory factors were positively correlated with the number of acute asthma attacks,the average number of hospitalizations and the average length of hospital stay(P<0.05),negatively with the rate of MP-IgM-positive conversion into MP-IgM negative(P<0.05).Conclusion The levels of peripheral blood inflammatory factors in children patients with asthma complicated with MP infection are significantly reduced after treatment.The greater the reductions,the better the prognosis.
作者
贺晓红
顾星
黄仕琼
何进
HE Xiaohong;GU Xing;HUANG Shiqiong;HE Jin(Department of General Pediatrics,Chengdu First People's Hospital,Chengdu 610000,Sichuan,China;Department of Pediatrics,Xichang People's Hospital,Xichang 615000,Sichuan,China)
出处
《贵州医科大学学报》
CAS
2021年第10期1169-1173,共5页
Journal of Guizhou Medical University
基金
2019年第二批四川省卫生健康科研课题普及项目(19PJ286)。
关键词
哮喘
肺炎支原体
患儿
炎性因子
动态变化
预后
相关性
asthma
Mycoplasma pneumoniae
children patients
inflammatory factors
dynamic changes
prognosis
correlation
