摘要
目的探讨金荞麦胶囊联合吸入用布地奈德混悬液治疗小儿支气管哮喘的临床疗效。方法选取2021年6月—2022年6月重庆市荣昌区人民医院接受治疗的92例支气管哮喘患儿,按照随机数字表法将所有患儿分为对照组和治疗组,每组各46例。对照组患儿雾化吸入吸入用布地奈德混悬液,将药液挤入雾化器的药杯内进行,1 mg/次,2次/d;治疗组在对照组基础上口服金荞麦胶囊,3粒/次,3次/d。两组患儿均连续治疗2周。观察两组的临床疗效,比较两组的症状缓解时间、肺功能指标、炎症因子和免疫功能指标。结果治疗后,治疗组患儿总有效率为95.65%,显著高于对照组总有效率82.61%(P<0.05)。治疗后,治疗组咳嗽消退时间、哮鸣音改善时间、喘息好转时间明显短于对照组(P<0.05)。治疗后,两组患者用力肺活量(FVC)、第1秒用力呼气量(FEV_(1))、最大呼吸峰流速值(PEF)高于治疗前(P<0.05);治疗组FVC、FEV_(1)、PEF明显高于对照组(P<0.05)。治疗后,两组患者血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于治疗前(P<0.05);与对照组相比,治疗组血清CRP、TNF-α、IL-6水平更低(P<0.05)。治疗后,两组患者血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平高于治疗前(P<0.05);与对照组相比,治疗组血清IgA、IgG、IgM水平更高(P<0.05)。结论金荞麦胶囊联合吸入用布地奈德混悬液治疗小儿支气管哮喘具有较好的临床疗效,可有效缓解患儿的临床症状,改善肺功能,降低炎症反应,提高免疫力,且安全性较高。
Objective To investigate the clinical effect of Jinqiaomai Capsules combined with Budesonide Suspension for inhalation in treatment of bronchial asthma in children.Methods Children(92 cases)with bronchial asthma in Chongqing Rongchang District People’s Hospital from June 2021 to June 2022 were divided into control and treatment groups according to the random number table method,and each group had 46 cases.Children in the control group were nebulization inhalation administered with Budesonide Suspension for inhalation,the drug solution was squeezed into the nebulizer cup,1 mg/time,twice daily.Children in the treatment group were po administered with Jinqiaomai Capsules on the basis of the control group,3 grains/time,three times daily.Children in two groups were treated for 2 weeks.After treatment,the clinical efficacies were evaluated,and the symptom relief time,lung function indicators,and the serum levels of CRP,TNF-α,IL-6,IgA,IgG,and IgM in two groups were compared.Results After treatment,the total effective rate of the treatment group was 95.65%,significantly higher than the control group's total effective rate of 82.61%(P<0.05).After treatment,the cough resolution time,wheezing sound improvement time,and wheezing improvement time in the treatment group were significantly shorter than those in the control group(P<0.05).After treatment,FVC,FEV_(1),and PEF of two groups were higher than before treatment(P<0.05).FVC,FEV_(1),and PEF in the treatment group were significantly higher than those in the control group(P<0.05).After treatment,the serum levels of CRP,TNF-α,and IL-6 in two groups were lower than before treatment(P<0.05).Compared with the control group,the levels of serum CRP,TNF-α,and IL-6 in the treatment group were lower(P<0.05).After treatment,the serum levels of IgA,IgG,and IgM in two groups were higher than before treatment(P<0.05).Compared with the control group,the levels serum of IgA,IgG,and IgM in the treatment group were higher(P<0.05).Conclusion Jinqiaomai Capsules combined with Budesonide Suspension for inhalation has clinical curative effect in treatment of bronchial asthma in children,can effectively relieve clinical symptoms of children,improve lung function,reduce inflammation,improve immunity,with good safety.
作者
唐智权
曾锤利
杨婷
姚大为
TANG Zhi-quan;ZENG Chui-li;YANG Ting;YAO Da-wei(Department of Pharmacy,Chongqing Rongchang District People’s Hospital,Chongqing 402460,China;Department of Respiration,Chongqing Rongchang District People’s Hospital,Chongqing 402460,China;Department of Pediatrics,Chongqing Rongchang District People’s Hospital,Chongqing 402460,China)
出处
《现代药物与临床》
CAS
2023年第7期1678-1682,共5页
Drugs & Clinic
基金
白求恩医学科学研究基金项目。
