摘要
目的分析早期肠内营养支持对结肠癌患者化疗期间营养状况及免疫功能的影响。方法便利选取该院2018年4月—2020年4月收治的112例结肠癌患者纳入观察研究中,采用双盲随机抽样法分成研究组和对照组,各56例。对照组采纳肠外营养支持,研究组采纳早期肠内营养支持,对比两组术后7 d后营养指标和免疫功能指标变化情况。结果术前两组前白蛋白、白蛋白、总蛋白、血红蛋白比较,差异无统计学意义(P>0.05);术后7 d,研究组前白蛋白(128.62±3.62)mg/L,对照组前白蛋白(121.16±1.62)mg/L,差异有统计学意义(t=14.076,P<0.05);研究组白蛋白(34.62±2.62)g/L、对照组白蛋白(31.15±1.05)g/L,差异有统计学意义(t=9.199,P<0.05);研究组总蛋白(59.62±2.62)g/L、对照组总蛋白(54.16±1.05)g/L,差异有统计学意义(t=14.475,P<0.05);研究组血红蛋白(128.62±3.62)g/L、对照组血红蛋白(123.26±2.11)g/L,差异有统计学意义(t=9.572,P<0.05),研究组术后7 d营养指标情况均明显高于对照组,差异有统计学意义(P<0.05);术前CD4^(+)、CD4^(+)/CD8^(+)、CD8^(+)比较,差异无统计学意义(P>0.05);术后7 d,研究组CD4^(+)为(63.85±6.14)%,对照组CD4^(+)(55.85±3.41)%,差异有统计学意义(t=8.523,P<0.05);研究组CD8^(+)(24.04±1.52)%,对照组CD8^(+)(28.85±2.67)%,差异有统计学意义(t=11.715,P<0.05);研究组CD4^(+)/CD8^(+)(1.52±0.18),对照组CD4^(+)/CD8^(+)(1.31±0.10),差异有统计学意义(t=7.631,P<0.05)。研究组术后免疫功能指标情况均明显优于对照组,差异有统计学意义(P<0.05)。结论早期肠内营养支持可有效改善结肠癌患者营养状况及免疫功能,效果优于肠外营养支持。
Objective To analyze the effect of early enteral nutrition support on the nutritional status and immune function of colon cancer patients during chemotherapy.Methods A total of 112 colon cancer patients admitted to the hospital from April 2018 to April 2020 were selected convenient and included in the observational study.They were divided into study group and control group by double-blind random sampling method,with 56 cases in each group.The control group adopted parenteral nutrition support,and the study group adopted early enteral nutrition support.The changes in nutritional and immune function indexes after 7 d after surgery were compared between the two groups.Results Before the operation,there was no significant difference between the two groups of albumin,albumin,total protein,and hemoglobin(P>0.05);7 d after the operation,the study group's prealbumin(128.62±3.62)mg/L,the control group Albumin(121.16±1.62)mg/L,the difference was statistically significant(t=14.076,P<0.05).Albumin in the study group(34.62±2.62)g/L and albumin in the control group(31.15±1.05)g/L,the difference was statistically significant(t=9.199,P<0.05);total protein in the study group(59.62±2.62)g/L,the total protein of the control group(54.16±1.05)g/L,the difference was statistically significant(t=14.475,P<0.05).The hemoglobin of the study group was(128.62±3.62)g/L and the hemoglobin of the control group(123.26±2.11)g/L,the difference was statistically significant(t=9.572,P<0.05),and the nutritional indicators of the study group were obvious after 7 d higher than the control group,the difference was statistically significant(P<0.05).There was no significant difference between CD4^(+),CD4^(+)/CD8^(+),and CD8^(+)before operation(P>0.05);7 days after operation,CD4^(+)in the study group was(63.85±6.14)%,and CD4^(+)in the control group(55.85±3.41)%,the difference was statistically significant(t=8.523,P<0.05).CD8^(+)(24.04±1.52)%in the study group and CD8^(+)(28.85±2.67)%in the control group,the difference was statistically significant(t=11.715,P<0.05).CD4^(+)/CD8^(+)(1.52±0.18)in the study group and CD4^(+)/CD8^(+)(1.31±0.10)in the control group,the difference was statistically significant(t=7.631,P<0.05).The postoperative immune function indexes of the study group were significantly better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Early enteral nutrition support can effectively improve the nutritional status and immune function of patients with colon cancer,and the effect is better than parenteral nutrition support,which is worth learning.
作者
朱园
ZHU Yuan(Department of Hematology Oncology,Department of Geriatrics,Guangzhou First People's Hospital,Guangzhou,Guangdong Province,510180 China)
出处
《中外医疗》
2021年第20期50-52,56,共4页
China & Foreign Medical Treatment
关键词
早期肠内营养支持
结肠癌
化疗
营养状况
免疫功能
Early enteral nutrition support
Colon cancer
Chemotherapy
Nutritional status
Immune function
