摘要
抑郁症是一种心理或情感障碍疾病,其发生与生理、心理、社会环境息息相关,临床上抑郁症常表现出显著持久的心情低落、思维与认知功能受损、活动能力减退,严重者还会出现自残、自杀等行为。抑郁症发病复杂多样,目前发病机制主要有神经递质假说、免疫缺陷假说、下丘脑-垂体-肾上腺(HPA)轴系统激活假说、脑源性神经营养因子(BDNF)假说及肠道菌群假说等,西医多以抗抑郁药物治疗抑郁症,但有副作用且容易反复发作,中医治疗抑郁症有明显优势,其从“气”“痰”,从“瘀”,从“五脏”论治者,皆言之有据,试之有效。抑郁症病程长反复发作,这与中医学“虚”的概念不谋而合,从虚论治是在中医理论指导下辨证论治抑郁症的一种治法,方证相应则药到病除,该文查阅近年来从虚论治抑郁症的相关临床与实验研究,从补气、补血、补阴、补阳4个方面对从虚论治抑郁症的方药研究进行综述,客观阐明从虚论治抑郁症方药的研究进展,以期丰富抑郁症的中医治疗理论,并为探求抑郁症的治疗提供新思路。
Depression is a mental or affective disorder,whose occurrence is closely related to the physical,psychological,and social environmental factors.Clinically,patients with depression often present with significant and long-lasting blue mood,impaired thinking and cognitive functions,reduced mobility,and even self-harm and suicide attempts.The pathogenesis of depression is complex and diverse,and there mainly exist the neurotransmitter hypothesis,immunodeficiency hypothesis,hypothalamus-pituitary-adrenal(HPA)axis activation hypothesis,brain-derived neurotrophic factor(BDNF)hypothesis,and intestinal flora hypothesis.In western medicine,it is mostly treated with antidepressant drugs,but the resulting side effects and repeated attack cannot be ignored.Traditional Chinese medicine(TCM)has obvious advantages in dealing with depression.The advocates of treating"Qi","phlegm","stasis",and"five zang organs"have all been proved effective.Depression is characterized by a long course of disease and repeated attack,which coincides with the concept of"deficiency"in TCM.Tonifying deficiency is a method for treating depression based on TCM syndrome differentiation.Under the guidance of this principle,the formulated prescriptions will produce the desired effects. This article reviewed the related clinical and experimental studies on depression treatment viadeficiency tonification in recent years,and summarized the corresponding prescriptions for benefiting Qi,replenishing blood,nourishing Yin,and tonifying yang,respectively,so as to enrich the TCM theory ofdepression and provide new ideas for its clinical treatment.
作者
亓新庆
亓雪梅
刘甜梦
粟栗
QI Xin-qing;QI Xue-mei;LIU Tian-meng;SU Li(School of Basic Medicine,Changchun University of Chinese Medicine,Changchun 130117,China;Taian Maternal and Child Health Hospital,Taian 271000,China;Changchun University of Chinese Medicine,Changchun 130117,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2021年第17期217-226,共10页
Chinese Journal of Experimental Traditional Medical Formulae
基金
吉林省教育厅科学研究项目(JJKH20210961KJ)。
关键词
抑郁症
虚
从虚论治
补气
补血
补阴
补阳
研究进展
depression
deficiency
treating from deficiency
benefiting Qi
replenishing blood
nourishing Yin
tonifying Yang
research progress
