摘要
目的:基于循证药学的方法,评价藿香正气口服制剂治疗胃肠功能紊乱的临床证据,为临床治疗和决策者提供循证依据。方法:计算机检索PubMed、the Cochrane Library、SinoMed、中国知网和万方数据库等数据库,收集藿香正气口服制剂治疗胃肠功能紊乱的系统评价/荟萃分析(Meta分析)(藿香正气口服制剂组为藿香正气口服制剂单药或联合其他药物治疗,对照组为安慰剂或其他阳性对照药物治疗),由2名研究者根据纳入与排除标准筛选文献、提取资料及评价质量后对结果进行综合分析。结果:共纳入4篇系统评价/Meta分析,多系统评价评估问卷(assessment of multiple systematic reviews,AMSTAR)平均分为6.3分。分析结果显示,藿香正气口服制剂可显著提高胃肠型感冒的临床有效率,在改善恶寒、发热和肠鸣腹泻方面的效果均显著优于西药;藿香正气口服制剂联合常规治疗或联合诺氟沙星治疗均可显著提高急性胃肠炎的总有效率,在改善发热、呕吐方面的效果显著优于单独应用常规治疗或诺氟沙星治疗,藿香正气口服制剂与诺氟沙星联合应用可显著改善腹痛、腹泻症状;藿香正气口服制剂对功能性消化不良的有效性与多潘立酮(或联合吉法酯)相当。安全性数据有限,结果显示,与对照组相比,藿香正气口服制剂组的不良反应发生率未显著增加。结论:藿香正气口服制剂治疗胃肠功能紊乱具有良好的有效性和安全性,特别是其与西医常规治疗联合应用时。但上述结果需要进一步开展高质量的临床研究加以验证。
OBJECTIVE:To evaluate the clinical evidence of Huoxiang Zhengqi oral preparation in the treatment of gastrointestinal dysfunction based on evidence-based pharmacy,so as to provide evidence-based evidence for clinical treatment and decision makers.METHODS:Systematic review/Meta-analysis on Huoxiang Zhengqi oral preparation in the treatment of gastrointestinal dysfunction(the Huoxiang Zhengqi oral preparation group was given Huoxiang Zhengqi oral preparation alone or in combination with other drugs,while the control group was given placebo or other positive control drugs)were collected after retrieving PubMed,the Cochrane Library,SinoMed,CNKI and Wanfang database,two researchers performed comprehensive analysis after literature screening,data extracting and quality evaluation according to the inclusion and exclusion criteria.RESULTS:Totally 4 pieces of systematic review/Meta-anlysis were involved,with the average score of assessment of multiple systematic reviews(AMSTAR)was 6.3 points.Results of analysis indicated that the Huoxiang Zhengqi oral preparation can significantly improve the clinical effective rate in the treatment of gastrointestinal cold,which also had significantly better effect than western medicine in improving chills,fever and bowel diarrhea;Huoxiang Zhengqi oral preparation combined with conventional treatment or combined with norfloxacin can significantly improve the total effective rate in the treatment of acute gastroenteritis,which had significantly better effect in improving fever and vomiting than that of conventional treatment or norfloxacin alone,the combined application of Huoxiang Zhengqi oral preparation and norfloxacin can significantly improve the symptoms of abdominal pain and diarrhea;the effectiveness of Huoxiang Zhengqi oral preparation on functional dyspepsia was equivalent to domperidone(or combined with gefaxacin).Due to the limited safety data,the results show that compared with the control group,the incidence of adverse drug reactions in the Huoxiang Zhengqi oral preparation group did not increase significantly.CONCLUSIONS:Huoxiang Zhengqi oral preparation has good effectiveness and safety in the treatment of gastrointestinal dysfunction,especially in combination with western conventional therapy.While the above result still need to be validated by additional high-quality clinical researches.
作者
曹苗苗
门鹏
温剑
刘丽
杨毅恒
赵荣生
CAO Miaomiao;MEN Peng;WEN Jian;LIU Li;YANG Yiheng;ZHAO Rongsheng(Dept.of Pharmacy,Peking University Third Hospital,Beijing 100191,China;Peking University Health Science Center’s Institute for Drug Evaluation,Beijing 100191,China;Beijing Center for Pharmaceutical Quality Control and Improvement,Beijing 100191,China)
出处
《中国医院用药评价与分析》
2021年第5期600-602,607,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
藿香正气口服制剂
循证评价
胃肠功能紊乱
胃肠型感冒
急性胃肠炎
功能性消化不良
有效性
安全性
Huoxiang Zhengqi oral preparation
Evidence-based evaluation
Gastrointestinal dysfunction
Gastrointestinal cold
Acute gastroenteritis
Functional dyspepsia
Effectiveness
Safety
