摘要
目的探讨肾毒清灌肠液联合血液透析治疗急性肾衰竭的临床疗效及其对血清炎性因子的影响。方法选取吉安市中医院2018年1月—2020年1月收治的急性肾衰竭患者62例,随机分为血液透析组和联合组,各31例。血液透析组予以血液透析治疗,联合组在血液透析组基础上予以肾毒清灌肠液治疗。2组均连续治疗1个月。比较2组治疗前后β2微球蛋白(β2-MG)、血肌酐(SCr)、尿素氮(BUN)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、白介素23(IL-23),并观察2组不良反应发生情况。结果治疗前2组β2-MG、SCr、BUN、IL-6、TNF-α、IL-23比较,差异无统计学意义(P>0.05);治疗后联合组β2-MG、SCr、BUN、IL-6、TNF-α、IL-23低于血液透析组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论肾毒清灌肠液联合血液透析治疗急性肾衰竭的临床疗效确切,可有效改善患者肾功能,降低炎性因子水平,且安全性较高。
Objective To explore the clinical effect and impact on serum inflammatory factors of Shenduqing enema combined with hemodialysis in the treatment of acute renal failure.Methods A total of 62 cases of patients with acute renal failure were selected from January 2018 to January 2020 in Ji’an Hospital of Traditional Chinese Medicine,which were randomly divided into hemodialysis group and combined group,31 cases in each group.The hemodialysis group was treated with hemodialysis,the combined group was treated with Shenduqing enema on the basis of hemodialysis group.Both groups were treated continuously for one month.β2-MG,SCr,BUN,IL-6,TNF-α,IL-23 before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results Before treatment,there was no significant difference inβ2-MG,SCr,BUN,IL-6,TNF-αand IL-23 between the two groups(P>0.05);after treatment,β2-MG,SCr,BUN,IL-6,TNF-αand IL-23 in combined group were lower than those in hemodialysis group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shenduqing enema combined with hemodialysis have an exact clinical effect for acute renal failure,which can effectively improve the renal function of patients and reduce the level of inflammatory factors,and with high safety.
作者
陈贵平
CHEN Guiping(Department of Internal Mediciney Ji'an Hospital of Traditional Chinese Medicine,Ji'an 343009,China)
出处
《临床合理用药杂志》
2021年第12期4-6,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
肾衰竭
肾毒清灌肠液
血液透析
治疗结果
肾功能
Renal failure
Shenduqing enema
Haemodialysis
Treatment outcome
Kidney function
