摘要
目的研究女性生殖道人乳头瘤病毒(HPV)基因分型与宫颈病变的相关性。方法选取汕头大学医学院附属潮州市人民医院2015年2月~2020年2月收治的648例行宫颈组织病理活检的受检者,按宫颈病变程度分为A组(高度鳞状上皮内病变患者,124例)、B组(低度鳞状上皮内病变患者,308例)、C组(宫颈炎患者,216例),所有受检者均进行HPV基因分型检测,以阴道镜下活检作为诊断的金标准,分析HPV基因分型与宫颈病变的相关性。结果HPV基因分型检测结果显示,纳入研究的648例患者中HPV阳性105例,HPV阳性率为16.20%。其中A组HPV阳性41例;B组阳性53例;C组阳性11例,感染率最高的HPV亚型依次为HPV 52、16、81、58、68、53、33、18、39。A组的HPV阳性数、高危型HPV(HR-HPV)、多亚型感染例数大于B组、C组,B组的HPV阳性数、HR-HPV、多亚型感染数大于C组,差异均有统计学意义(P<0.05);多因素分析结果提示,HPV感染(β=0.053,OR=1.763,95%CI=1.332~2.245)、HR-HPV感染(β=0.078,OR=2.452,95%CI=1.502~3.547)是宫颈癌的危险因素(P<0.05)。结论HPV感染可增加女性宫颈病变发生风险,且HR-HPV感染是宫颈癌的独立危险因素。
Objective To study the correlation between Human papillomavirus(HPV)genotyping in female genital tract and cervical lesions.Methods From February 2015 to February 2020,a total of 648 patients with cervical biopsy in Chaozhou People′s Hospital Affiliated to Shantou University Medical College were selected and divided into group A(124 patients with high-grade squamous intraepithelial lesions),group B(308 patients with low-grade squamous intraepithelial lesions)and group C(216 patients with cervicitis)according to the degree of cervical lesions.HPV genotyping was performed in all patients to analyze the correlation between HPV genotypes and cervical lesions.Results The results of HPV genotyping showed that 105 patients were HPV positive among 648 patients,and the HPV positive rate was 16.20%.Among them,41 cases were HPV positive in group A,53 cases were HPV positive in group B,11 cases were HPV positive in group C.The HPV subtypes with the highest infection rate were HPV 52,16,81,58,68,53,33,18 and 39.The number of HPV positive,high-risk HPV(HR-HPV)and multi subtype infection in group A was higher than that in group B and group C,and the number of HPV positive,HR-HPV and multi subtype infection in group B was higher than that in group C(P<0.05).The results of multivariate analysis showed that HPV infection(β=0.053,OR=1.763,95%CI=1.332-2.245)and HR-HPV infection(β=0.078,OR=2.452,95%CI=1.502-3.547)were risk factors for cervical cancer(P<0.05).Conclusion HPV infection can increase the risk of cervical lesions in women,and HR-HPV infection is an independent risk factor for cervical cancer.
作者
陈新瑶
张健
丁燕佳
莫焕桐
CHEN Xin-Yao;ZHANG Jian;DING Yan-jia;MO Huan-tong(Department of Central Laboratory,Chaozhou People′s Hospital Affiliated to Shantou University Medical College,Guangdong Province,Chaozhou521011,China)
出处
《中国当代医药》
CAS
2021年第14期181-183,187,共4页
China Modern Medicine
基金
广东省医学科学技术研究基金项目(B2019232)。
