摘要
新型冠状病毒肺炎是由新型冠状病毒(新冠病毒)引起的新发传染病。新冠病毒侵入人体后,刺激免疫系统产生多种特异性抗体,来减弱或清除病原体对机体的影响。研究新冠病毒感染后人体内特异性抗体动态变化特征对于疾病认识、诊断、以及疫苗研究与防控策略制定具有重要意义。本文对国内外关于新冠病毒感染者不同类型特异性抗体产生和持续时间、抗体水平及其可能的影响因素等方面的相关研究进行归纳分析,从而增进对新冠病毒感染后机体免疫学特征的了解。
COVID-19 is an emerging infectious disease caused by SARS-CoV-2.After the infection of the virus,the host immune system is stimulated to produce multifarious specific antibodies to decrease or eliminate effects of the pathogen.Study of the specific antibodies dynamic characteristics in patients with COVID-19 is very important for the understanding and diagnosis of the disease,research and development of vaccine,and planning of prevention and control strategy.This paper reviews and summarizes the domestic and oversea research on dynamic characteristics of specific antibodies of COVID-19 patients,including the antibody producing,duration and level,and its possible influencing factors in order to improve the understanding of the immunological characteristics of COVID-19.
作者
赵宏婷
彭质斌
杨孝坤
李志丽
任敏睿
秦颖
孙校金
余建兴
安志杰
毛乃颖
许文波
李中杰
Zhao Hongting;Peng Zhibin;Yang Xiaokun;Li Zhili;Ren Minrui;Qin Ying;Sun Xiaojin;Yu Jianxing;An Zhijie;Mao Naiying;Xu Wenbo;Li Zhongjie(Division of Infectious Disease,Key Laboratory of Infectious Disease Surveillance and Early-warning,Chinese Center for Disease Control and Prevention,Beijing 102206,China;Branch of Respiratory Disease,Division of Infectious Disease,Key Laboratory of Infectious Disease Surveillance and Ear-warning,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Immunization Programme,Chinese Center for Disease Control and Prevention,Beijing 100050,China;National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China;National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China)
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2021年第1期39-43,共5页
Chinese Journal of Epidemiology
基金
国家重点研发项目(2020YFC0846900)
国家自然科学基金(82041029)。
