摘要
背景:产前诊断筛查技术的发展使得产前治疗成为可能。对于多种胎儿遗传性疾病,宫内干细胞治疗具有显著的优势。目的:通过目前已有的实验研究和临床资料分析宫内干细胞治疗产前胎儿疾病的可行性。方法:应用计算机检索中国知网、万方医学网、PubMed数据库中的相关文献,检索时间从建库至2020-06-16,检索中文关键词为“宫内干细胞治疗,胎儿”,英文关键词为“in utero stem cell therapy,fetal”。结果与结论:随着产前诊断筛查技术和干细胞治疗技术的发展,宫内干细胞在多种胎儿遗传性疾病治疗中具有显著的优势。胎儿自身发育的生理特点也为宫内干细胞移植提供了条件。临床前动物实验研究从嵌合体植入水平和免疫耐受等方面为宫内干细胞移植治疗的临床应用奠定了基础。近年来,产前诊断筛查技术的发展,伴随高通量分子检测、微创手术等方法,可在妊娠早期检测出多种胎儿疾病,也使得产前宫内治疗成为可能。
BACKGROUND:The development of prenatal diagnosis and screening technology has made prenatal treatment possible.For a variety of fetal genetic diseases,in utero stem cell therapy has significant advantages.OBJECTIVE:To analyze the feasibility of in utero stem cell therapy in prenatal fetal diseases through the existing experimental research and clinical data.METHODS:Databases of PubMed,Wanfang and CNKI were searched for the articles published from the inception to June 16,2020.The keywords were“in utero stem cells,fetal”in English and Chinese,respectively.RESULTS AND CONCLUSION:With the development of prenatal diagnosis screening technology and stem cell therapy technology,in utero stem cell therapy has a significant advantage in the treatment of various fetal genetic diseases.The physiological characteristics of fetal development also provide conditions for in utero stem cell transplantation.The preclinical animal experiment research has laid the foundation for the clinical application of in utero stem cell transplantation treatment from the aspects of chimera implantation level and immune tolerance.In recent years,the development of prenatal diagnosis and screening technology,along with high-throughput molecular testing and minimally invasive surgery,can detect a variety of fetal diseases in early pregnancy,and also makes prenatal intrauterine treatment possible.
作者
揭秋玲
孙菲
Jie Qiuling;Sun Fei(Department of Obstetrics and Gynecology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China;Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research,Department of Reproductive Medicine,Hainan Provincial Clinical Research Center for Thalassemia,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan Province,China;Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Medical University,Haikou 570102,Hainan Province,China;Haikou Key Laboratory for Preservation of Human Genetic Resource,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第31期5034-5039,共6页
Chinese Journal of Tissue Engineering Research
基金
广东省基础与应用基础研究基金面上项目(2019A1515010019),项目负责人:孙菲
南方医科大学南方医院院长基金(2018Z014,2017C001),项目负责人:孙菲
国家自然科学基金(81660433),项目参与人:孙菲。
关键词
宫内干细胞
免疫
遗传性疾病
严重联合免疫缺陷症
造血干细胞
间充质干细胞
羊水干细胞
治疗
综述
in utero stem cell therapy
immunity
hereditary diseases
severe combined immunodeficiency
hematopoietic stem cell therapy
mesenchymal stem cell therapy
amniotic fluid stem cell
therapy
review
