摘要
目的:探析冠心病合并高血压患者血清一氧化氮(NO)、脂蛋白相关磷脂酶A2(Lp-PLA2)、同型半胱氨酸(Hcy)水平与颈动脉粥样硬化程度的相关性。方法:2018年1月-2019年5月收治冠心病合并高血压患者50例,作为观察组;另选取同期健康体检人员50例,作为对照组。比较两组相关指标水平。结果:观察组血清Hcy、Lp-PLA2水平高于对照组,NO水平低于对照组,差异有统计学意义(P<0.05)。观察组患者Grous平均积分为(2.801±0.41)分;Grous积分与血清NO负相关,与血清Hcy、Lp-PLA2与Grous积分正相关。结论:冠心病合并高血压患者血清NO水平低,Hcy和Lp-PLA2水平高。
Objective:To explore and analyze the correlation between serum nitric oxide(NO),lipoprotein associated phospholipase A2(Lp-PLA2)and homocysteine(Hcy)levels with carotid atherosclerosis in patients with coronary heart disease complicated with hypertension.Methods:From January 2018 to May 2019,50 patients with coronary heart disease complicated with hypertension were selected as the observation group.In addition,50 healthy physical examinees in the same period were selected as the control group.The relevant indicators level between the two groups was compared.Results:Serum Hcy and Lp-PLA2 levels of patients in the observation group were higher than the control group,and serum NO levels were lower than the control group,with the differences were statistically significant(P<0.05).The average Grous score in the observation group was(2.801±0.41)points.Grous integral was negatively correlated with serum NO,and positively correlated with serum Hcy,Lp-PLA2 and Grous integral.Conclusion:Serum NO level is low in patients with coronary heart disease complicated with hypertension,Hcy and Lp-PLA2 levels are high.
作者
宋子敬
郑文
訾化蓉
李晓蓉
Song Zijing;Zheng Wen;Zi Huarong;Li Xiaorong(Department of Cardiovascular Neurology,People's Hospital of Jiuquan City,Gansu Jiuquan 735019;Department of New Town Cardiovascular Neurology,People's Hospital of Jiuquan City,Gansu Jiuquan 735019;Department of New Town Ultrasound Medicine,People's Hospital of Jiuquan City,Gansu Jiuquan 735019;Department of New Town Outpatient,People's Hospital of Jiuquan City,Gansu Jiuquan 735019)
出处
《中国社区医师》
2020年第32期58-59,共2页
Chinese Community Doctors
关键词
颈动脉粥样硬化
高血压
冠心病
Carotid atherosclerosis
Hypertension
Coronary heart disease
