摘要
目的探讨重组人脑利钠肽联合左西孟旦治疗急性心力衰竭的临床疗效及对患者血乳酸(LA)、N末端B型利钠肽原(NT-proBNP)水平的影响。方法选取医院2017年7月至2019年7月收治的急性心力衰竭患者92例,随机分为观察组和对照组,各46例。两组患者均给予急性心力衰竭的基础治疗,并给予左西孟旦注射液静脉泵注,观察组患者加用注射用重组人脑利钠肽静脉滴注,均持续治疗1周。结果观察组总有效率为89.13%,明显高于对照组的71.74%(P<0.05);治疗后,观察组患者的左室射血分数(LVEF)明显高于对照组,左室收缩末期内径(LVESd)、左室舒张末期内径(LVEDd)均明显小于对照组,QT间期离散度(QTd)及LA和NT-proBNP水平均明显低于对照组(P<0.05);观察组患者出院时的生理健康、心理健康、社会关系和周围环境评分均明显高于对照组(P<0.05);观察组与对照组不良反应发生率相当(15.22%比8.70%,P>0.05)。结论重组人脑利钠肽联合左西孟旦治疗急性心力衰竭疗效良好,可改善心功能及LA与NT-proBNP的水平,提高生存质量。
Objective To investigate the clinical efficacy of recombinant human brain natriuretic peptide(rhBNP)combined with levosimendan in the treatment of acute heart failure(AHF)and its effect on the levels of blood lactic acid(LA)and N-terminal pro-brain natriuretic peptide(NT-proBNP).Methods Totally 92 patients with AHF admitted to our hospital from July 2017 to July 2019 were selected and randomly divided into the observation group and the control group,46 cases in each group.The patients in the two groups were given the basic treatment of AHF,and treated with Levosimendan Injection by the intravenous pump,on this basis,the patients in the observation group were treated with rhBNP by intravenous drip.Both groups were continuously treated for 1 week.Results The total effective rate of the observation group was 89.13%,which was significantly higher than 71.74%of the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was significantly higher than that in the control group,the left ventricular end-systolic diameter(LVESd)and left ventricular end-diastolic diameter(LVEDd)in the observation group were significantly shorter than those in the control group,QT interval dispersion(QTd)and the levels of LA and NT-proBNP in the observation group were significantly lower than those in the control group(P<0.05).The scores of physical health,mental health,social relation and the surrounding environment in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(15.22%vs.8.70%,P>0.05).Conclusion rh BNP combined with levosimendan is effective in the treatment of AHF,it can improve cardiac function,the levels of LA and NT-proBNP,and the quality of life.
作者
沈青青
王计亮
彭辉
齐素霞
SHEN Qingqing;WANG Jiliang;PENG Hui;QI Suxia(Xingtai Third Hospital,Xingtai,Hebei,China 054000)
出处
《中国药业》
CAS
2020年第22期57-59,共3页
China Pharmaceuticals
基金
河北省医学科学研究课题[20191676]。
关键词
急性心力衰竭
左西孟旦
重组人脑利钠肽
血乳酸
N末端B型利钠肽原
临床疗效
生存质量
acute heart failure
levosimendan
recombinant human brain natriuretic peptide
blood lactate
N-terminal pro-brain natriuretic peptide
clinical efficacy
quality of life
