摘要
目的探讨逍遥散联合恩替卡韦对慢性乙型病毒性肝炎(CHB)患者乙肝病毒的脱氧核糖核酸(HBV-DNA)阴转率、乙型肝炎e抗原(HBe Ag)阴转率的影响。方法选取2019年2—8月庄河市中心医院感染性疾病科收治的CHB56例作为研究对象,将其按照随机数字表法分为对照组(26例)与观察组(30例)。对照组给予单一恩替卡韦治疗,观察组在此基础上联合逍遥散治疗,比较两组治疗前后肝功能指标及HBV-DNA阴转率、HBe Ag阴转率及丙氨酸转氨酶(ALT)复常率变化情况。结果两组治疗后ALT、AST、TBi L降低,且观察组低于对照组,ALB升高,观察组高于对照组,差异有统计学意义(P<0.05);观察组治疗后HBV-DNA阴转率、HBe Ag阴转率、ALT复常率高于对照组,差异有统计学意义(P<0.05)。结论对CHB患者给予逍遥散联合恩替卡韦治疗疗效显著,可以有效改善肝功能,提高HBV-DNA阴转率及HBe Ag阴转率。
Objective To explore the effect of Xiaoyao Powder combined with entecavir on Hepatitis B virus deoxyribonucleic acid(HBV-DNA)negative conversion rate and hepatitis B e antigen(HBeAg)negative conversion rate in patients with hepatitis B(CHB).Methods A total of Fifty-six cases of chronic hepatitis B admitted to the infectious diseases department of Zhuanghe Central Hospital from February to August 2019 were selected as the research objects and were divided into a control group(26 cases)and an observation group(30 cases)according to the method of random number table.The control group was treated with single entecavir,and the observation group was treated with Xiaoyao Powder on the bases of the control group.The changes of liver function index and HBVDNA negative conversion rate,HBeAg negative conversion rate and ALT recurrence rate were compared and analyzed before and after treatment.Results The ALT、AST、TBi I of the 2 groups were lower than those before treatment,and those of the observation group were lower than the control group.The difference was statistically significant(P<0.05).After treatment,the HBVDNA negative conversion rate,the HBeAg negative conversion rate,ALT recovery rate were significantly higher than those in the control group and the difference was statistically significant(P<0.05).Conclusion The effect of Xiaoyao Powder combined with entecavir in patients with chronic hepatitis B is remarkable,which can effectively improve HBV DNA negative conversion rate and HBeAg conversion rate.
作者
白洁
BAI Jie(Department of Infectious Diseases,Zhuanghe Central Hospital,Dalian 116400,China)
出处
《中国药物经济学》
2020年第8期113-115,共3页
China Journal of Pharmaceutical Economics
关键词
慢性乙型病毒性肝炎
逍遥散
恩替卡韦
乙肝病毒脱氧核糖核酸阴转率
乙型肝炎e抗原阴转率
Chronic hepatitis B
Xiaoyao Powder
Entecavir
Hepatitis B virus deoxyribonucleic acid negative conversion rate
Hepatitis B e antigen negative conversion rate
