摘要
目的:探究氧氟沙星滴耳液用于急性化脓性中耳炎治疗的临床效果及安全性。方法:以2019年2月-2020年1月收治的急性化脓性中耳炎患者200例为对象,分析病原菌分布情况,随后将所有患者分为参照组100例与研究组100例,参照组实施氯霉素滴耳液治疗,研究组实施盐酸左氧氟沙星滴耳液治疗,对比两组患者的治疗效果、病原菌清除率、不良反应,进行统计学分析。结果:所有患者病原菌分布,金黄色葡萄球菌58例(29.00%),肺炎链球菌47例(23.50%),化脓性链球菌32例(16.00%),流感嗜血杆菌25例(12.50%),卡他莫拉球菌38例(16.00%)。治疗有效率,研究组明显优于参照组,差异有统计学意义(P<0.05)。病原菌清除率,研究组明显优于参照组(P<0.05)。不良反应发生率,研究组明显优于参照组,差异有统计学意义(P<0.05)。结论:急性化脓性中耳炎诱发原因主要为病原菌感染,以金黄色葡萄球菌、流感嗜血杆菌、肺炎链球菌等为主要病原菌,需结合抗生素的敏感试验实施抗生素治疗;另外,急性化脓性中耳炎患者使用盐酸左氧氟沙星滴耳液治疗,有效提高治疗有效率,促进病原菌清除,预防不良反应,安全性高,治疗效果显著。
Objective:To investigate the clinical effect and safety of Ofloxacin ear drops for the treatment of acute suppurative otitis media.Method:A total of 200 patients with acute suppurative otitis media from February 2019 to January 2020 were taken as the target.The distribution of pathogens was analyzed.All patients were divided into a reference group of 100 cases and a study group of 100 cases.The reference group was treated with Chloramphenicol Ear Drops,and the study group was treated with Levofloxacin Hydrochloride Ear Drops.The treatment effects,pathogen clearance,and adverse reactions were compared between the two groups for statistical analysis.Result:The distribution of pathogens in all patients was as follows,staphylococcus aureus 58 cases (29.00%),streptococcus pneumoniae 47 cases (23.50%),streptococcus pyogenes 32 cases (16.00%),Haemophilus influenzae 25 cases (12.50%),and 38 cases of Moraxella catarrhalis (16.00%).For the treatment efficiency,the study group was significantly better than the reference group,with statistical significance (P<0.05).For the pathogen removal rate,the research group was significantly better than the reference group (P<0.05).For the incidence of adverse reactions,the study group was significantly better than the reference group,with statistical significance (P<0.05).Conclusion:The cause of acute suppurative otitis media is mainly caused by pathogenic infections.Staphylococcus aureus,Haemophilus influenzae,and Streptococcus pneumoniae are the main pathogenic bacteria,and antibiotic treatment must be performed in combination with antibiotic sensitivity tests.In addition,patients with acute suppurative otitis media use Hydrochloric Levofloxacin Ear Drops treatment can effectively improve the treatment efficiency,promote the removal of pathogenic bacteria,prevent adverse reactions,high safety,and significant treatment effects.
作者
黄威
黄瑞通
HUANG Wei;HUANG Ruitong(The Sixth People’s Hospital of Huizhou,Huizhou 516000,China)
出处
《中外医学研究》
2020年第27期150-152,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
基金
惠州市科技计划项目(180605161743377)。
关键词
急性化脓性中耳炎
盐酸左氧氟沙星滴耳液
氯霉素滴耳液
安全性
Acute suppurative otitis media
Levofloxacin Hydrochloride Ear Drops
Chloramphenicol Ear Drops
Safety
