摘要
目的基于中医传承辅助系统软件,探讨中医治疗儿童闭塞性细支气管炎的用药特点及组方规律。方法收集、整理河南中医药大学第一附属医院儿科呼吸病区治疗儿童闭塞性细支气管炎的处方,采用关联规则apriori算法、复杂系统熵聚类等无监督数据挖掘方法,确定处方中各种药物的使用频次及药物之间的关联规则,分析中医治疗儿童闭塞性细支气管炎的用药特点及组方规律。结果共录入122条处方,109味中药,其中使用频次高于50的中药共20味,支持度为72,置信度为0.96时,共有药物组合22组,此外还挖掘出治疗本病的28个核心配伍和14个新处方。结论儿童闭塞性细支气管炎病机总与痰、瘀、虚、闭有关,治疗主张分期论治,急性期用药多为清肺化痰、止咳平喘、祛瘀通络之品,此外,应重视温阳扶正药物的使用。
Objective To study the rules of drug administration and prescription in traditional Chinese medicine(TCM)treatment for children with bronchiolitis obliterans based on TCM inheritance system software.Methods The prescriptions for bronchiolitis obliterans in children were collected and sorted out in respiratory ward of Pediatric Department of the First Hospital Affiliated to Henan University of Traditional Chinese Medicine.The unsupervised data-mining methods,such as the Apriori algorithm and the complex system entropy clustering,were adopted to find out frequency of drug use and the association rules among drugs,and to analyze the characteristics of drug use and the prescription rules in TCM treatment for children with bronchiolitis obliterans.Results A total of 122 prescriptions were included,involving 109 Chinese medicines.Twenty kinds of medicines were used more than 50 times;when the support degree was 72 and the confidence degree was 0.96,there were 22 drug combinations.In addition,28 core compatible combinations and 14 new prescriptions were discovered,which could be used in the treatment of the disease.Conclusion The pathogenesis of bronchiolitis obliterans in children is associated with stagnation of sputum,blood stasis,deficiency and blockade.The treatment should be performed according to phases.During the acute phase,the drugs with the effect of clearing lungs and reducing phlegm,relieving cough and asthma and dispelling stasis and dredging collaterals,should be used;besides,attention should be paid to the use of drugs for warming Yang and strengthening body.
作者
宋桂华
王艳会
孙萌萌
张冰雪
韩慧珍
SONG Guihua;WANG Yanhui;SUN Mengmeng;ZHANG Bingxue;HAN Huizhen(Henan University of Traditional Chinese Medicine, Zhengzhou 450009,China)
出处
《中国中西医结合儿科学》
2020年第4期312-316,共5页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
儿童大叶性肺炎中医诊疗方案规范化研究(2018JDZX117)
河南省特色学科中医学学科建设项目(STS-ZYX-2017012)
河南省中医药科学研究专项(2015ZY02035)。
关键词
闭塞性细支气管炎
中医治疗
急性期
关联规则
聚类算法
Bronchiolitis obliterans
TCM treatment
Acute phase
Association rules
Clustering algorithm
