摘要
脑组织细胞之间存在广泛的缝隙连接蛋白和泛连接蛋白。由神经元、神经胶质细胞和血管细胞构成的神经血管单元通过缝隙连接蛋白和泛连接蛋白构成的细胞膜通道整合和处理信息,从而维持神经系统的动态平衡。脑缺血后,细胞膜通道通过参与兴奋毒性、炎症反应、血脑屏障损伤等病理机制在缺血性脑损伤中发挥着重要作用。因此,维持缝隙连接蛋白和泛连接蛋白的正常功能对于保护神经元免受缺血性脑损伤至关重要。
There are a wide range of gap junction proteins and pannexins between brain cells.The neurovascular unit,which are composed of neurons,glial cells and vascular cells,integrate and process information through cell membrane channels composed of gap junction proteins and pannexins,so as to maintain the dynamic balance of the nervous system.After cerebral ischemia,cell membrane channels play an important role in ischemic brain injury by participating in excitatory toxicity,inflammatory response,blood-brain barrier injury and other pathological mechanisms.Therefore,maintaining the normal function of gap junction proteins and pannnexins is essential to protect neurons from ischemic brain injury.
作者
王新月
陈应柱
于海龙
蒋瓅
Wang Xinyue;Chen Yingzhu;Yu Hailong;Jiang Li(Dalian Medical University,Dalian 116044,China;Department of Neurology,Northern Jiangsu People's Hospital,Yangzhou 225000,China)
出处
《国际脑血管病杂志》
2020年第6期472-476,共5页
International Journal of Cerebrovascular Diseases
关键词
脑缺血
连接蛋白类
缝隙接合部
谷氨酸
炎症
血脑屏障
Brain ischemia
Connexins
Gap junctions
Glutamic acid
Inflammation
Blood-brain barrier
