摘要
目的比较连续性肾脏替代(CRRT)和间歇性血液透析(IHD)治疗重症急性肾衰竭的临床效果。方法选取2016年1月-2018年10月于广东省肇庆市第二人民医院ICU接受治疗的重症急性肾衰竭患者60例,采用随机数字表法分为观察组与对照组各30例。观察组使用CRRT治疗,对照组使用IHD治疗。治疗1周后对比2组患者的血流动力学指标,利用多功能监测仪监测患者心率(HR)、平均动脉压(MAP)和心脏指数(CI);比较2组患者治疗前后肾功能,包括尿素氮、血肌酐及内生肌酐清除率。结果治疗后,2组患者HR均明显减慢,MAP及CI明显升高,且观察组变化幅度大于对照组(P <0. 05);治疗后,2组患者尿素氮、血清肌酐及内生肌酐清除率均优于治疗前,且观察组优于对照组(P <0. 05)。结论 CRRT治疗重症急性肾衰竭有较好的效果,更有利于稳定血流动力学指标及改善肾功能,具有一定的临床参考价值。
Objective To compare the clinical effects of continuous renal replacement(CRRT)and intermittent hemodialysis(IHD)in the treatment of severe acute renal failure.Methods 60 patients with severe acute renal failure who were treated in the ICU of The Second People’s Hospital of Zhaoqing City,Guangdong Province from January 2016 to October 2018 were selected.Random number table method was used to divide the observation group and control group,each of 30 cases.The observation group was treated with CRRT,and the control group was treated with IHD.After 1 week of treatment,the hemodynamic indexes of the two groups of patients were compared,and the heart rate(H R),mean arterial pressure(MAP),and cardiac index(CI)of the patient were monitored using a multi-function monitor;The renal function indexes of the two groups before and after treatment were compared,including urea nitrogen,serum creatinine and endogenous creatinine clearance.Results After treatment,the HR of the two groups were significantly slowed,MAP and CI were significantly increased,and the observation group changed more than the control group(P<0.05);After treatment,the clearance rates of urea nitrogen,serum creatinine and endogenous creatinine in the two groups were better than before treatment,and the observation group was better than the control group(P<0.05).Conclusion CRRT has a better effect in treating severe acute renal failure,and is more conducive to stabilizing hemodynamic indicators and improving renal function,has certain clinical reference value.
作者
廖梅嫣
潘朝勇
吴家圣
吴海宾
曾汇霞
LIAO Meiyan;PAN Chaoyong;WU Jiasheng(ICU,The Second Peopled Hospital of Zhaoqing,Guangdong Province,Zhaoqing 526060,China)
出处
《临床合理用药杂志》
2020年第16期27-28,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
连续性肾替代治疗
间歇性血液透析
重症急性肾衰竭
临床效果
Continuous renal replacement therapy
Intermittent hemodialysis
Severe acute renal failure
Clinical effect
