摘要
神经退行性疾病是由神经元结构或功能逐渐丧失导致认知及运动障碍的一类不可逆损伤性疾病,目前尚无安全有效的治疗方法。探索无创的物理治疗手段在神经退行性疾病中的应用潜力,对疾病缓解与有效控制具有重大的意义。光学疗法是利用光线与组织的相互作用,通过光化学或光物理反应治疗疾病和促进机体康复的方法,具有精准性和微创性的技术特点。其中,弱光治疗作为一种无创光疗类型,在促进伤口愈合、缓解疼痛、炎症消退、组织再生等方面已广泛应用于临床。临床研究也证实弱光治疗能够有效改善神经退行性疾病病患的病理症状,作为一种无创物理疗法,弱光治疗为神经退行性疾病的缓解和有效控制提供了非常具有前景的新方向。本文综述了弱光治疗在神经退行性疾病中的研究进展,并结合光电子技术的发展展望其应用前景,研究提出:需阐明弱光作用机理及量效关系,开发新型弱光治疗技术,完善临床验证体系及评价指标,尽快造福病患,服务社会。
Neurodegenerative diseases are a heterogeneous group of irreversible illnesses caused by the progressive loss of neuronal structure or function,leading to cognitive and movement disorders,without safe and effective treatments.Exploring the application potential of non-invasive physical therapy for neurodegenerative diseases is of great significance for disease remission and effective control.Phototherapy is a method that uses the interaction of light and tissue to treat diseases and promote the rehabilitation of the body through photochemical or photophysical reactions,with precise and minimally invasive features.Low-light therapy is a type of non-invasive phototherapy that is used in promoting wound healing,pain relief,inflammation regression,and tissue regeneration.Clinical studies have also confirmed that low-light therapy can effectively improve the pathological symptoms of patients with neurodegenerative diseases.Thus,as a non-invasive physical therapy,low-light therapy provides a promising new direction for the relief and effective control of neurodegenerative diseases.This article summarizes the research progress of low-light therapy for neurodegenerative diseases and prospects its application in conjunction with the development of optoelectronic technology.It is suggested that the mechanism and dose effect relationship of low light should be clarified,new low-light treatment technology should be developed,and the clinical verification system and evaluation index should be improved,so as to benefit patients and serve the society as soon as possible.
作者
魏勋斌
周非凡
陶乐婵
杨思华
顾波波
Wei Xunbin;Zhou Feifan;Tao Lechan;Yang Sihua;Gu Bobo(Biomedical Engineering Department,Peking University,Beijing 100191,China;Med-X Research Institute&School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China;College of Physics and Optoelectronic Engineering,Shenzhen University,Shenzhen 518061,Guangdong,China;MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science,College of Biophotonics,South China Normal University,Guangzhou 510631,China)
出处
《中国工程科学》
CSCD
北大核心
2020年第3期108-116,共9页
Strategic Study of CAE
基金
中国工程院咨询项目“我国激光技术与应用2035发展战略研究”(2018-XZ-27)。
关键词
光学疗法
弱光治疗
无创疗法
神经退行性疾病
phototherapy
low-light therapy
non-invasive physical therapy
neurodegenerative diseases
