摘要
抑郁症是一种患病率高、易复发、自杀率高的精神障碍疾病,容易导致认知功能损伤等问题.光疗以无创、副作用小、疗效快等优势受到广泛的关注,为调节抑郁症生物节律和睡眠障碍等症状提供了新的可能性.光信号通过视网膜神经节细胞投射到抑郁脑区参与非视觉成像功能,激活神经细胞活动,分泌神经递质使神经通路产生生理性改变,对生物机体的昼夜节律、情绪、睡眠产生调控作用,达到改善抑郁行为的目的.光的波长、剂量和最佳作用模式与治疗效果息息相关,但目前光疗的最佳应用模式仍存在争议.为了全面促进光疗在生命科学领域以及临床上的应用,仍需进行大量的临床与模型动物光学参数研究.本文从光疗路径、不同光谱作用机制、光学参数、作用疗效、存在问题及展望进行综述,促进光疗调控抑郁症的深入研究.
Depression is a kind of mental disorder with high prevalence rate,easy relapse and high suicide rate,which can easily lead to cognitive impairment and other problems.Phototherapy,with its advantages of noninvasive,less side effects and quick curative effect,has attracted wide attention,which provides a new possibility for regulating the biorhythm and sleep disorders of depression.Light signals are projected through retinal ganglion cells to depressed brain areas to participate in non-visual imaging functions,activating nerve cell activity,secreting neurotransmitters to induce physiological changes in neural pathways,and regulating circadian rhythms,mood,and sleep in the biological organism to improve depressive behavior.The most common forms of light therapy include bright light therapy,blue light therapy and near infrared light therapy.The choice and use of different light sources can have different effects on the therapeutic outcome,and their wavelength,dose and optimal mode of action are closely related to the therapeutic outcome.The results also suggest that the use of low intensity beneficial wavelengths of blue light can have the same antidepressant effect as high intensity bright light therapy,but the best mode of application of phototherapy is still controversial.In order to promote the application of phototherapy in the field of life science and clinical practice,a large number of studies on optical parameters in clinical and animal models are still needed.This paper will summarize the current therapeutic targets of light therapy in depression-related brain regions and downstream neural circuits,explore the mechanisms of action of different spectra and their therapeutic parameters,discover the advantages of their light sources and suitable therapeutic parameters,and propose the problems of phototherapy,such as the optimal light parameters,the universality of different populations,and the safety issues arising from unsuitable light sources,which are still to be solved.As phototherapy continues to be explored in depth,the selection of optimal phototherapy pathways,the screening of optimal light parameters,and the combination of other classical therapeutic methods will provide references for experimental studies and clinical applications of phototherapy against depression and produce breakthroughs in the treatment of depression.
作者
陈洪丽
高静静
杨佳佳
姜忠迪
陈瑞娟
刘爽
明东
CHEN Hong-Li;GAO Jing-Jing;YANG Jia-Jia;JIANG Zhong-Di;CHEN Rui-Juan;LIU Shuang;MING Dong(Academy of Medical Engineering and Translational Medicine,Tianjin University,Tianjin 300072,China;Tianjin Key Laboratory of Optoelectronic Detection Technology and Systems,School of Life Sciences,Tiangong University,Tianjin 300387,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2021年第12期1422-1428,共7页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金项目(61705164,81630051)
天津市“项目+团队”重点培养专项(XB202007)
天津市自然科学基金项目(19JCQNJC01600)资助。
关键词
光疗
强光
蓝光
光照参数
抑郁症
phototherapy
bright light
blue light
optical parameters
depression
