摘要
目的探讨补元汤合桂枝茯苓丸对中晚期非小细胞肺癌(NSCLC)患者免疫功能的改善作用。方法选取2016年6月—2018年6月我院肿瘤科收治的中晚期NSCLC患者126例为研究对象,随机分为对照组和观察组,各63例。对照组患者采用GP化疗方案,观察组在对照组的基础上联合补元汤合桂枝茯苓方加减。采用FCM法测定两组T淋巴细胞亚群CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平,免疫比浊法测定两组免疫球蛋白IgA、IgG、IgM水平。结果观察组治疗有效率高于对照组,但差异无统计学意义(P>0.05);观察组疾病控制率显著高于对照组(P<0.05)。治疗前,两组患者CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平比较,差异均无统计学意义(P>0.05);治疗后,两组患者CD3^+、CD4^+、CD4^+/CD8^+水平显著高于治疗前,且观察组显著高于对照组(P<0.05),CD8^+水平显著低于治疗前,且观察组显著低于对照组(P<0.05)。治疗前,两组患者IgA、IgG、IgM水平比较,差异无统计学意义(P>0.05);治疗后,两组患者IgA、IgG、IgM水平均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05)。两组患者不良反应发生率比较,差异均无统计学意义(P>0.05)。结论补元汤合桂枝茯苓丸对中晚期NSCLC患者的疗效显著,可明显改善机体免疫功能,缓解化疗相关不良反应,值得临床推广应用。
Objective To investigate the effects of Buyuan decoction and Guizhi Fuling pills on immune function of patients with middle and advanced non-small cell lung cancer(NSCLC).Methods A total of 126 patients with middle and advanced NSCLC admitted to oncology department of our hospital between June 2016 and June 2018 were randomly divided into two groups,63 patients in each group.Patients in the control group were treated with GP chemotherapy,while those in the observation group were treated with Buyuan decoction and Guizhi Fuling add or subtraction prescription on the base of GP chemotherapy.The levels of T lymphocyte subsets CD3^+,CD4^+,CD8^+,and the CD4^+/CD8^+were determined by FCM.And the levels of immunoglobulin IgA,IgG and IgM were determined by immunoturbimetry.The differences of clinical efficacy and immune function were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group,but difference showed no statistical significance(P>0.05).The disease control rate of the observation group was significantly higher than that of the control group(P<0.05).Before treatment,there were no statistical differences in the levels of CD3^+,CD4^+,CD8^+,and the CD4^+/CD8^+between the two groups(P>0.05).After treatment,the CD3^+and CD4^+levels,and the CD4^+/CD8^+in the two groups were all significantly higher than those before treatment,while CD8^+level was significantly lower than that before treatment(P<0.05).In addition,the levels of CD3^+and CD4^+,and the CD4^+/CD8^+of the observation group were significantly higher than those of the control group,and CD8^+level was significantly lower than that of the control group(P<0.05).Before treatment,there were no statistical differences in IgA,IgG and IgM levels between the two groups(P>0.05).After treatment,the IgA,IgG and IgM levels were significantly higher than those before treatment in both groups(P<0.05),and they were even significantly higher in observation group than in control group(P<0.05).No statistical difference was found in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Buyuan decoction and Guizhi Fuling pills could improve the immune function,and make a significant curative effect on middle and advanced NSCLC patients.
作者
龚年金
梁欢
GONG Nianjin;LIANG Huan(Department of Respiratory Medicine,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,Hubei,445000,China;Department of Obstetrics and Gynecology,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,Hubei,445000,China)
出处
《肿瘤药学》
CAS
2020年第2期232-236,共5页
Anti-Tumor Pharmacy
关键词
非小细胞肺癌
补元汤
桂枝茯苓丸
免疫功能
Non-small cell lung cancer
Buyuan decoction
Guizhi Fuling pills
Immune function
