摘要
目的探讨项八针联合吞咽康复训练对假性延髓麻痹吞咽障碍患者血清VEGF、TGF-β1的影响。方法选取2017年1月~2019年1月本院收治的假性延髓麻痹吞咽障碍患者136例,依据不同治疗方法分为观察组和对照组,各68例,两组均行常规药物治疗,对照组在此基础上采用项八针治疗,观察组采用项八针联合吞咽康复训练治疗,比较两组患者治疗前后标准吞咽功能评估(SSA)评分、电视透视吞咽功能检查(VFSS)评分、血清血管内皮细胞生长因子(VEGF)、转化生长因子-β1(TGF-β1)水平的差异,并统计临床疗效。结果观察组和对照组治疗前的SSA评分、VFSS评分、VEGF和TGF-β1水平比较,差异无统计学意义(P>0.05);治疗后,两组患者SSA评分较治疗前明显降低,VFSS评分、VEFG、TGF-β1水平较治疗前明显升高(P<0.05);观察组患者治疗后的临床有效率高于对照组(94.12%vs 75.00%),差异有统计学意义(P<0.05)。结论项八针联合吞咽康复训练能较好改善假性延髓麻痹吞咽障碍患者的吞咽功能,疗效优于单纯项八针治疗,其作用机制可能与调节血清VEGF、TGF-β1的代谢、促进血管生成、保护神经元有关。
Objective To explore the effect of cervical eight-needle combined with swallowing rehabilitation training on serum VEGF and TGF-β1 in patients with pseudobulbar paralysis dysphagia. Methods 136 patients with pseudobulbar paralysis dysphagia admitted to our hospital from January 2017 to January 2019 were randomly divided into observation group and control group, 68 cases in each group. Both groups were given routine drug treatment. The control group was additionally given cervical eight-needle treatment,and the observation group was additionally given cervical eight-needle treatment combined with swallowing rehabilitation training. The differences of standard swallowing function assessment(SSA) score, TV fluoroscopy function(VFSS) score, serum vascular endothelial growth factor(VEGF) and transforming growth factor-β1(TGF-β1) levels before and after treatment were compared between the two groups. The clinical efficacy of the groups was evaluated and the occurrence of adverse reactions was recorded. Results Before treatment,there was no significant difference in SSA score, VFSS score, VEGF and TGF-β1 between the two groups(P>0.05). After treatment, the SSA scores of the two groups were significantly lower than those before treatment;The VFSS score, VEFG and TGF-β1 levels were significantly higher than those before treatment(P<0.05). The total effective rate of the observation group was significantly higher than that of the control group(94.12% vs 75.00%), The difference was significant(P<0.05). Conclusion The cervical eight-needle combined with swallowing rehabilitation training can improve the swallowing function of patients with pseudobulbar paralysis dysphagia. The curative effect is better than that of simple cervical eight-needle treatment. The mechanism may be related to the regulation of serum VEGF and TGF-β1 metabolism,promotion of angiogenesis and protection of neurons.
作者
王罗丹
郎伯旭
方震宇
WANG Luodan;LANG Boxu;FANG Zhenyu(Department of Acupuncture,Massage and Rehabilitation,Taizhou Municipal Hospital,Taizhou318000,China)
出处
《中国现代医生》
2020年第9期7-10,共4页
China Modern Doctor
基金
浙江省中医药优秀青年人才基金项目(2016ZQ035)。
关键词
项八针
吞咽康复训练
假性延髓麻痹
吞咽障碍
血管内皮细胞生长因子
转化生长因子-Β1
Cervical eight-needle
Swallowing rehabilitation training
Pseudobulbar paralysis
Dysphagia
Vascular endothelial growth factor
Transforming growth factor-β1
