摘要
糖尿病患者有70%~80%死于心血管并发症,已成为其死亡的主要原因。糖尿病患者心血管并发症主要与血管内皮功能障碍和新生血管形成不良有关,其重要影响因素是内皮祖细胞数量改变和功能异常。糖尿病患者的高血糖可导致内皮祖细胞功能障碍,抑制其增殖能力,血管形成能力和旁分泌作用。文章旨在综述糖尿病患者的高血糖对内皮祖细胞数量和功能影响的相关机制以及内皮祖细胞在治疗糖尿病心血管病变中的应用,为防治糖尿病患者心血管并发症提供研究思路。
70%to 80%of people with diabetes died from cardiovascular complications,which had become the leading cause of death in diabetic patients.Cardiovascular complications in diabetic patients are mainly associated with vascular endothelial dysfunction and poor neovascularization.Its important influencing factors are changes in the number of endothelial progenitor cells and dysfunction.Hyperglycemia in diabetic patients can cause endothelial progenitor cell dysfunction,inhibit its proliferation ability,angiogenesis ability and paracrine effect.In order to provide research ideas for the prevention and treatment of cardiovascular complications in diabetic patients,this article aims to review the relevant mechanism of the effect of hyperglycemia on the number and function of endothelial progenitor cells in patients with diabetes,and the application of endothelial progenitor cells in the treatment of diabetic cardiovascular disease.
作者
刘玉花
翟露(综述)
赵德锋
戴霞(审校)
LIU Yu-hua;ZHAI Lu;ZHAO De-feng;DAI Xia(Department of Respiratory Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;Department of Stem Cell Transplantation,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;Department of Cardiology,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China;Department of Nursing,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China)
出处
《医学研究生学报》
CAS
北大核心
2020年第1期88-92,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金（81660147）
关键词
糖尿病
内皮祖细胞
心血管
diabetes
endothelial progenitor cells
cardiovascular
