摘要
目的观察化痰通遂汤治疗痰浊壅塞、瘀阻经络型脑卒中偏瘫的临床效果,并进行初步机制探讨。方法选取河北以岭医院2015年1月~2016年12月收治的脑卒中偏瘫患者120例,以随机数字表法将其分为对照组与治疗组,各60例。治疗组给予基础治疗加康复训练并口服化痰通遂汤,每天一剂,分早晚两次服用,连续45 d;对照组除不用化痰通遂汤外,其余与治疗组相同。治疗前后分别对患者的临床症状进行评分,采用Fugl-Meyer量表对患者进行上肢运动功能评分,并以表面肌电图仪测定三角肌、肱三头肌、前臂伸肌肌群最大等长收缩时肌电积分(iEMG)。检测两组治疗前后血清总胆固醇(TC)、三酰甘油(TG)、血液流变学指标(包括全血黏度、纤维蛋白原及血浆黏度)。结果与治疗前比较,治疗后两组临床症状评分均降低(P<0.05),两组临床症状评分比较差异无统计学意义(P>0.05);两组上肢运动功能评分及iEMG均升高,且治疗组高于对照组(P<0.05);两组TC与TG水平均降低,且治疗组低于对照组(P<0.05);治疗后对照组各血液流变学指标变化差异无统计学意义(P>0.05),治疗组全血黏度、血浆黏度及纤维蛋白原含量降低,且低于对照组(P<0.05)。结论化痰通遂汤联合康复训练对痰浊壅塞、瘀阻经络型脑卒中偏瘫患者有良好的治疗效果,其作用可能与降低血脂、改善血液流性有关。
Objective To analyze the clinical effect and the possible mechanism of Huatan Tongsui Decoction in the treatment of the stroke patients with hemiplegia.Methods A total of 120 stroke hemiplegia patients in Yiling Hospital of Hebei Province from January 2015 to December 2016.According to the random number table method they were divided into control group and treatment group,with 60 cases in each group.The treatment group was given basic treatment plus rehabilitation training and oral Huatan Tongsui Decoction,one dose a day,taken twice in the morning and evening for 45 days.The control group was given the same treatment as the treatment group except for Huatan Tongsui Decoction.The clinical symptoms were scored before and after treatment,and the upper limb motor function was evaluated by Fugl-Meyer scale.The electromyography score(iEMG)of deltoid muscle,triceps brachii muscle and extensor muscle group of forearm were detected by the surface electromyography.The serum total cholesterol(TC),triglyceride(TG),and hemorheology indexes(including whole blood viscosity,fibrinogen and plasma viscosity)were measured before and after treatment in two groups.Results Compared with before treatment,the clinical symptom scores of two groups were decreased after treatment(P<0.05).There were no significant differences in clinical symptom scores between two groups(P>0.05).The scores of upper limb motor function and iEMG in two groups were both increased,and those in treatment group were higher than those in control group(P<0.05).The levels of TC and TG in two groups were decreased and those in treatment group were lower than those in control group(P<0.05).There were no significant differences in hemorheology indexes in the control group after treatment(P>0.05).Total blood viscosity,plasma viscosity and fibrinogen content were decreased in treatment group(P<0.05),and those in treatment group were lower than those in control group(P<0.05).Conclusion The mechanism of Huatan Tongsui Decoction treating stroke may be related to reducing serum triglyceride,improving blood rheology,so as to improve the clinical symptoms of the patients.
作者
王晶
刘春茹
孙永辉
王苗苗
纪月然
WANG Jing;LIU Chunru;SUN Yonghui;WANG Miaomiao;JI Yueran(Department of Rehabilitation,Yiling Hospital of Hebei Province,Hebei Province,Shijiazhuang050091,China)
出处
《中国医药导报》
CAS
2020年第2期105-108,共4页
China Medical Herald
基金
河北省科技计划项目(142777117D)
关键词
化痰通遂汤
康复训练
痰浊壅塞、瘀阻经络型脑卒中
偏瘫
HuatanTongsui Decoction
Rehabilitation training
Phlegm congestion and stasis obstructing meridian type stroke
Hemiplegia
