摘要
研究表明,在一些特定的条件如糖尿病、胰岛素抵抗、肥胖、妊娠等代谢应激过程中,胰岛α细胞可被诱导表达激素原转换酶1/3,进而产生有生物活性的胰高血糖素样肽-1(GLP-1)。这种在代谢应激条件下被激活的胰岛内源性GLP-1信号可能通过局部旁分泌形式作用于邻近的β细胞,作为保护胰岛β细胞免受代谢应激损伤的内源性适应性代偿性机制。而且,多种生理及病理因素如GLP-1、葡萄糖依赖性促胰岛素释放肽、胰岛素、胆囊收缩素及细胞因子如白细胞介素-6、基质细胞衍生因子-1等都可以通过多种细胞内信号机制调节胰岛内源性GLP-1信号的表达。以增强内源性GLP-1信号为靶点的药物可能用于糖尿病的治疗。
Recent studies have shown that isletαcells are induced to express prohormone convertases 1/3 and produce biologically active glucagon-like peptide(GLP)-1 under certain conditions such as diabetes,insulin resistance,obesity,pregnancy and other metabolic stress process.The endogenous GLP-1 signaling induced by metabolic stress may act on the adjacentβcells in a local paracrine manner,which acts as an endogenous adaptive compensatory mechanism to protect isletβcells from stress damage.Moreover,many factors such as GLP-1,gastric inhibitory polypeptide,insulin,cholecystokinin,and cytokines such as interleukin-6,stromal cell-derived factor-1,etc,can regulate the expression of endogenous GLP-1 in islets through a variety of intracellular signaling mechanisms.Drugs that target endogenous GLP-1 signaling in the islets may be a new and effective treatment for type 2 diabetes.
作者
杨梦萦
袁莉
Yang Mengying;Yuan Li(Department of Endocrinology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)
出处
《国际内分泌代谢杂志》
2019年第6期413-418,共6页
International Journal of Endocrinology and Metabolism
