摘要
长链非编码RNA在多种人类肿瘤中扮演重要角色。小核仁RNA宿主基因15(small nuclear RNA host gene 15, SNHG15)作为一个新发现的长链非编码RNA,在胃癌、肝癌、胰腺癌等多种人类肿瘤中高表达。异常表达的SNHG15与患者的临床特征密切相关,并通过不同机制调节肿瘤细胞的增殖、抗凋亡、侵袭和转移。SNHG15有可能成为肿瘤诊断和治疗的潜在靶点。本文就SNHG15在肿瘤发生、发展中的作用及潜在分子机制作一综述。
Long non-coding RNAs(lncRNAs) play pivotal roles in various human tumors. Small nuclear RNA host gene 15(SNHG15) is a novel long non-coding RNA, and is upregulated in different human cancers as gastric cancer, hepatocellular carcinoma, pancreatic cancer and so on. The ectopic expression of SNHG15 is correlated with the clinical symptoms of cancer patients, and regulates cellular proliferation, anti-apoptosis, invasion and metastasis by different mechanisms in tumors. SNHG15 might be regarded as a potential diagnostic biomarker and a novel therapeutic target for tumors. This paper reviews the research progress of the functions and potential mechanisms of SNHG15 in the occurrence and development of malignant tumors.
作者
周原世
高泽玮
黄荣菊
唐恩雨
胡增涛
姜兴明
ZHOU Yuanshi;GAO Zewei;HUANG Rongju;TANG Enyu;HU Zengtao;JIANG Xingming(Department of Biliary and Pancreatic Surgery , the Second Affiliated Hospital of Harbin Medical University , Harbin 150086 , China)
出处
《中华实用诊断与治疗杂志》
2019年第10期1029-1032,共4页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家自然科学基金(81602088)
中国博士后科学基金(2017M621305)
黑龙江省博士后科学基金(LBH-Z16096)
黑龙江省卫生计生委科研课题(2016-049)
大学生创新创业训练计划项目(201810226105)
哈尔滨医科大学创新科学研究基金(2016LCZX09)
