摘要
目的探究急性脑梗死患者血清水通道蛋白1(AQP1)、水通道蛋白4(AQP4)、血管内皮生长因子(VEGF)表达与脑水肿严重程度的关系。方法选取急性脑梗死患者78例为观察组,另选取健康者80例为对照组,采用酶联免疫吸附试验检测血清AQP1、AQP4、VEGF水平,应用无创脑水肿动态监护仪测定电阻抗扰动系数值判断脑水肿严重程度,根据电阻抗扰动系数将观察组分为重度组(>9.5)及轻度组(7.5<电阻抗扰动系数≤9.5),分析其血清AQP1、AQP4、VEGF表达与脑水肿严重程度的相关性,应用Logistic回归模型对影响脑水肿严重程度的因素进行分析。结果观察组血清AQP1、AQP4、VEGF水平与电阻抗扰动系数均显著高于对照组(P<0.05);血清AQP1、AQP4、VEGF水平均与电阻抗扰动系数呈显著正相关(均P<0.05);重度组血清AQP1、AQP4、VEGF均显著高于轻度组(P<0.05);高血压、AQP1、AQP4、VEGF是影响脑水肿严重程度的危险因素(均P<0.05)。结论急性脑梗死患者血清AQP1、AQP4、VEGF表达异常,呈显著升高趋势,并与脑水肿形成密切相关,其表达水平越高脑水肿程度越严重。
Aim To explore the relationship between the expression of serum aquaporin 1(AQP1),aquaporin 4(AQP4),vascular endothelial growth factor(VEGF)and the severity of cerebral edema in patients with acute cerebral infarction.Methods 78 patients with acute cerebral infarction were selected as the observation group and 80 healthy people were selected as the control group,enzyme-linked immunosorbent assay was used to detect the levels of serum AQP1,AQP4 and VEGF,the severity of brain edema was judged by measuring the electrical impedance disturbance coefficient with non-invasive dynamic monitor.According to the electrical impedance disturbance coefficient,the observation group was divided into severe group(>9.5)and mild group(7.5<electrical impedance disturbance coefficient≤9.5).The correlation between the expression of AQP1,AQP4,and VEGF in serum and the severity of brain edema was analyzed by Logistic regression analysis,Logistic regression model was used to analyze the factors influencing the severity of brain edema.Results The levels of serum AQP1,AQP4,VEGF and electrical impedance disturbance coefficient in observation group were significantly higher than those in control group(P<0.05);serum AQP1,AQP4 and VEGF levels were positively correlated with electrical impedance disturbance coefficient(P<0.05);serum AQP1,AQP4,VEGF of severe group were significantly higher than those of mild group(P<0.05);hypertension,AQP1,AQP4 and VEGF were the risk factors affecting the severity of cerebral edema(P<0.05).Conclusion The expression of AQP1,AQP4 and VEGF in the patients with acute cerebral infarction are abnormal,and it shows a significant trend,and is closely related to the formation of cerebral edema,the higher the expression level of these three factors,the more serious the degree of brain edema is.
作者
安宏娜
陈玮
吾红光
吴斌
徐倩
吴小兵
AN Hongna;CHEN Wei;WU Hongguang;WU Bin;XU Qian;WU Xiaobing(Department of Neurology,Quzhou Second People's Hospital,Quzhou,Zhejiang 324000,China)
出处
《中国动脉硬化杂志》
CAS
2019年第11期956-959,964,共5页
Chinese Journal of Arteriosclerosis
基金
浙江省医药卫生科技计划项目(20172096)
