摘要
目的 :研究鼻咽癌的遗传变异特性。方法 :采用激光微切割技术分离鼻咽癌细胞DNA ,用比较基因组杂交检测 6例鼻咽癌组织。结果 :6q1 2 2 2、8q染色体区域的扩增 ,染色体 1 1 q2 3 2 4、1 3q基因缺失。 结论 :鼻咽癌具有染色体变异 ,其中 6q1 2 2 2、8q、1 1 q2 3 2 4和 1
Purpose To observe for genetic alterations in nasopharyngeal carcinoma (NPC). Methods six cases of NPC carcinoma were detected by laser capture microdissection to obtain pure tumour DNA and CGH analysis. Results The identified common chromosomal alterations included gain of chromosomes 6q12 22,8q as well as loss of chromosomes 11q23 24 and 13q were detected. Conclusion There are characteristic changes in 6q12 22,8q,11q23 24,and13q, some unknown genes located in the above regions might be of importance for the pathogenesis of NPC.
出处
《临床与实验病理学杂志》
CAS
CSCD
2002年第5期503-505,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
鼻咽癌
比较基因组杂交
诊断
nasopharyngeal neoplasms
comparative genomic hybridization
