摘要
随着全球肥胖和代谢综合征发病率的逐年升高,非酒精性脂肪性肝病(NAFLD)成为严重威胁人类的公共健康问题,现已位居我国慢性肝病之首。NAFLD的发病机制中的“多重打击”学说被广泛接受,由炎症因子引起的慢性低度炎症参与了NAFLD整个病理生理过程。促炎因子和抗炎因子失衡是单纯性脂肪肝进展为脂肪性肝炎、晚期肝纤维化和肝硬化的重要环节之一。研究炎症因子的表达与作用机制对阐明NAFLD发病机制及寻找有效的干预治疗措施具有重要意义。
With the increasing prevalence of obesity and metabolic syndrome,non-alcoholic fatty liver disease(NAFLD)has become a serious health problem worldwide and has replaced chronic hepatitis B to be the most common type of chronic liver disease in China.In the study of the pathogenesis of NAFLD,the"multiple strikes"theory is widely accepted which considers that systemic low-grade inflammation is involved in the entire pathological process.The imbalance between pro-inflammatory and anti-inflammatory factors is one of the important links in the progression of simple fatty liver to steatohepatitis,advanced liver fibrosis and cirrhosis.The research on the expression and mechanism of inflammatory factors is of great significance for elucidating the pathogenesis of NAFLD and finding effective interventions.
作者
陈洁
陈佳良
肖琨珉
段绍杰
梁叶莺
姚树坤
CHEN Jie;CHEN Jialiang;XIAO Kunmin;DUAN Shaojie;LIANG Yeying;YAO Shukun(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Gastroenterology,China-Japan Friendship Hospital,Beijing 100029,China)
出处
《医学综述》
2019年第15期2949-2954,共6页
Medical Recapitulate
基金
北京市科技计划课题(Z171100001717008)
中央高校基本科研业务费专项资金
中日友好医院生物医学转化工程系列研究项目(PYBZ1815)
