摘要
非酒精性脂肪性肝病(NAFLD)的特点是其以肝细胞脂肪变性和脂肪贮积为病理特征,其肝脏组织病理的演变从单纯的肝脂肪变性到肝细胞损伤的脂肪性肝炎,最终发展为肝纤维化和肝硬化,甚至肝癌。由于NAFLD与代谢综合征、结直肠肿瘤密切相关,甚至可以导致残疾、死亡,故早期诊断非酒精性脂肪性肝炎,明确肝纤维化程度尤为重要。其中肝活组织检查作为诊断NAFLD肝脏组织病理学分级、分期的金标准,一直在肝纤维化诊断中占据主要位置,但由于肝活组织检查的局限性促使近年来无创诊断技术迅速发展。单独的血清学模型、影像学检查诊断非酒精性脂肪性肝炎、早期肝纤维化的敏感度、特异度尚待提高。主要就进展性NAFLD的联合无创诊断方法进展作一综述。
Nonalcoholic fatty liver disease(NAFLD)is characterized by the pathological feature of hepatocyte fatty degeneration and lipid accumulation,and liver histopathology evolves from simple liver fatty degeneration to steatohepatitis with hepatocellular injury and finally progresses to liver fibrosis,liver cirrhosis,and even liver cancer.NAFLD is closely associated with metabolic syndrome and colorectal tumors and can even lead to disability and death,and therefore,it is of great importance to diagnose nonalcoholic steatohepatitis(NASH)as early as possible and clarify liver fibrosis degree.As the gold standard for determining the liver histopathological grade and stage of NAFLD,liver biopsy has always been a main method for the diagnosis of liver fibrosis.However,the limitations of liver biopsy have greatly promoted the rapid development of noninvasive diagnostic techniques in recent years.The sensitivity and specificity of serology models and imaging tests in the diagnosis of NASH and early-stage liver fibrosis need to be improved.This article reviews the advances in noninvasive diagnostic methods for progressive NAFLD.
作者
龚航
李良平
GONG Hang;LI Liangping(Department of Gastroenterology,Zunyi Medical University,Zunyi,Guizhou 563003,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2019年第2期406-410,共5页
Journal of Clinical Hepatology
关键词
非酒精性脂肪性肝病
诊断技术和方法
综述
non-alcoholic fatty liver disease
diagnostic techniques and procedures
review
