摘要
目的:观察万古霉素联合美罗培南对化脓性脑膜炎患儿血清C反应蛋白(CRP)、S-100β蛋白(S-100β)、神经元特异性烯醇化酶(NSE)表达的影响。方法:选取某院收治的106例化脓性脑膜炎患儿,按照随机双盲法将其分为2组,每组各53例。对照组给予美罗培南治疗,在此基础上,观察组给予万古霉素治疗。观察2组临床疗效、临床症状改善时间及不良反应,并观察2组患儿血清CRP、S-100β、NSE水平变化。结果:治疗总有效率观察组高于对照组,差异有统计学意义(P<0.05);治疗后2组患儿血清CRP、S-100β、NSE均低于治疗前,且观察组降低更加显著,差异有统计学意义(P<0.05);对照组颅内高压消失时间、惊厥消失时间、退热时间及意识恢复时间高于观察组,差异有统计学意义(P<0.05);2组患儿均仅出现轻微恶心、呕吐症状,未对疗效产生影响。结论:万古霉素联合美罗培南治疗可有效降低化脓性脑膜炎患儿血清CRP、S-100β及NSE水平,改善临床症状,促进患儿病情转归,且联合用药具有一定的安全性。
Objective: To observe the effect of vancomycin combined with meropenem on serum C-reactive protein (CRP), S-100β protein (S-100β) and neuron-specific enolase (NSE) in children with purulent meningitis. Methods: 106 children with purulent meningitis in a hospital were randomly divided into two groups, 53 cases in each. The control group was given meropenem, and the observation group was treated with vancomycin based on the regimen of the control group. The clinical efficacy, improvement time of clinical symptoms, and adverse reactions in the two groups were observed. The changes of serum CRP, S-100β and NSE were analyzed. Results: Compared with the control group, the total effective rate of the observation group was higher ( P <0.05). After treatment, serum CRP, S-100β and NSE in the two groups were lower than before the treatment, and the observation group decreased more significantly ( P <0.05). It took longer time before disappearance of intracranial hypertension and convulsions, fever relief, and recovery of consciousness in the control group than in the observation group ( P <0.05). There were only mild nausea and vomiting symptoms in the two groups, which did not affect the efficacy. Conclusion: Vancomycin combined with meropenem in treatment of children with purulent meningitis, in addition to certain safety, can effectively decrease the levels of serum CRP, S-100β and NSE, improve clinical symptoms, and promote the outcome of the disease.
作者
罗淑芬
LUO Shu-fen(Department of Pharmacy, The People's Hospital of Xuchang City, Henan 461000, China)
出处
《淮海医药》
CAS
2019年第4期353-355,共3页
Journal of Huaihai Medicine
