摘要
目的 探讨美罗培南治疗化脓性脑膜炎患儿的临床效果及价值评价。方法 选取2009年1月～2012年12月医院化脓性脑膜炎患儿88例,参考随机数字表法,按照1∶1比例将纳入者随机分为观察组和对照组,每组44例。对照组采用头孢曲松和阿莫西林舒巴坦,观察组采用注射用美罗培南。比较2组患儿体温下降时间、颅高压消失时间、脑髓液恢复正常时间、临床疗效和细菌学疗效及不良反应。结果 治疗后,观察组痊愈率68.18%、总有效率95.45%,高于对照组的45.45%、65.91%,差异有统计学意义（P〈0.05）。观察组细菌清除率为65.91%,高于对照组的43.18%,差异有统计学意义（P〈0.05）。观察组未清除率2.27%、替换率2.27%和再感染率2.27%低于对照组的18.18%、9.09%、9.09%,差异有统计学意义（P〈0.05）。观察组体温下降时间、颅高压消失时间及CSF恢复正常时间均较对照组明显缩短,差异有统计学意义（P〈0.05）。观察组消化道症状、神经系统症状及皮肤症状等不良反应率4.55%与对照组的4.55%比较,差异无统计学意义。结论 美罗培南治疗儿童化脓性脑膜炎效果显著,安全可靠,是化脓性脑膜炎患儿较为理想的选择,值得进一步扩大样本加以研究,为该药的合理化应用提供更多参考依据,服务临床。
Objective To investigate the clinical effect and value of meropenem in the treatment of purulent meningitis .Methods 88 patients with purulent meningitis in our hospital from January 2009 to December 2012 were randomly divided into observation group and control group, according to the proportion of 1：1, the subjects were randomly divided into observation group and control group, with 44 cases in each group.The control group was treated with ceftriaxone and amoxicillin sulbactam.The observation group was treated with meropenem for injection.Comparison of the two groups of children with temperature decline time, the time of disappearance of intracranial pressure, brain marrow fluid returned to normal time, clinical efficacy and bacteriological efficacy and adverse reactions.Results After treatment,The cure rate of the observation group was 68.18%, the total effective rate was 95.45%, higher than the control group 45.45%, 65.91%, the difference was statistically significant （ P〈0.05 ） .Bacterial clearance rate of the observation group was 65.91%, higher than the control group 43.18%, the difference was statistically significant （P〈0.05）.The unclear rate 2.27%, replacement rate 2.27%, and the re-infection rate 2.27% of the observation group were significantly lower than those of the control group 18.18%, 9.09%, 9.09%, the difference was statistically significant （P〈0.05）.The temperature decline time, the time of disappearance of intracranial pressure and CSF recovery time of the observation group were significantly shorter than the control group, the difference was statistically significant （P〈0.05）. Gastrointestinal symptoms, neurological symptoms and skin symptoms and other adverse reaction rate of 4.55% of the observation group compared with the control group 4.55%, the difference was not statistically significant.Conclusion Meropenem treatment of purulent meningitis in children with significant effect, safe and reliable, is purulent meningitis in children is an ideal choice, it is worth further expanding the sample to be studied for the rationalization of the drug to provide more reference basis for clinical services .
出处
《中国生化药物杂志》
CAS
2017年第3期255-257,261,共4页
Chinese Journal of Biochemical Pharmaceutics
