摘要
目的分析不同胰岛素给药方式对妊娠期糖尿病患者妊娠结局的影响。方法 128例妊娠期糖尿病患者,按照胰岛素给药方法的不同分为治疗a组与治疗b组,每组64例。治疗a组予胰岛素泵持续注射治疗,治疗b组予胰岛素皮下注射治疗,观察并比较两组患者血糖水平(空腹血糖、餐后2 h血糖)及糖化血红蛋白水平,记录并比较两组患者胰岛素用量及不良妊娠结局(剖宫产、妊娠高血压、羊水过多、低血糖)发生情况。结果治疗后,治疗a组患者空腹血糖、餐后2 h血糖、糖化血红蛋白分别为(4.7±1.3)mmol/L、(6.8±1.5)mmol/L、(6.2±1.0)%,均低于治疗b组的(5.9±2.1)mmol/L、(8.7±2.3)mmol/L、(7.8±0.9)%,差异具有统计学意义(P<0.05);治疗a组胰岛素用量(44.2±4.7)U/d低于治疗b组的(52.3±6.4)U/d,不良妊娠结局发生率18.75%低于治疗b组的40.63%,差异均具有统计学意义(P<0.05)。结论妊娠期糖尿病应用胰岛素泵持续皮下注射安全性高,且能够帮助患者缩短血糖达标时间,有效改善妊娠结局。
Objective To analyze the effect of different insulin administration methods on pregnancy outcome of gestational diabetes mellitus patients. Methods A total of 128 gestational diabetes mellitus patients were divided by different insulin administration methods into treatment group a and treatment group b, with 64 cases in each group. Treatment group a received subcutaneous insulin pump injection and group b received subcutaneous insulin injection. The blood glucose (fasting blood glucose, postprandial 2 h blood glucose) levels and glycosylated hemoglobin in the two groups were observed and compared. The insulin dosage and occurrence of adverse pregnancy outcomes (cesarean section, pregnancy- induced hypertension, polyhydramnios, hypoglycemia) were recorded and compared between the two groups. Results After treatment, treatment group a had lower fasting blood glucose, postprandial 2 h blood glucose levels and glycosylated hemoglobin respectively as (4.7± 1.3) mmol/L,(6.8±1.5) mmol/L and (6.2±1.0)% than (5.9±2.1) mmol/L,(8.7±2.3) mmol/L and (7.8±0.9)% in treatment group b, and their difference was statistically significant (P<0.05). Treatment group a had lower insulin dosage as (44.2±4.7) U/d than (52.3±6.4) U/d in treatment group b, and lower incidence of adverse pregnancy outcomes as 18.75% than 40.63% in treatment group b, and the difference was statistically significant (P<0.05). Conclusion Continuous subcutaneous injection of insulin pump in gestational diabetes mellitus is safe and can help patients shorten the time of blood glucose reaching standard and effectively improve pregnancy outcomes.
作者
任秀娥
REN Xiu-e(Department of Obstetrics, Dezhou Decheng District Maternal and Child Health Family Planning Service Center, Dezhou 253017, China)
出处
《中国现代药物应用》
2019年第11期21-23,共3页
Chinese Journal of Modern Drug Application
关键词
妊娠期糖尿病
胰岛素
胰岛素泵
Gestational diabetes mellitus
Insulin
Insulin pump
