摘要
目的分析左旋甲状腺素片治疗甲状腺功能减退症(甲减)对血脂代谢的影响与安全性。方法选取2016年2月至2017年9月我院收治的甲状腺功能减退患者92例作为研究对象,根据随机数字表法将其分为对照组和观察组,各46例。对照组给予甲状腺素片口服治疗,观察组给予左旋甲状腺素片口服治疗,两组用药疗程均为6个月。比较两组患者的临床疗效、血脂水平、甲状腺功能及不良事件发生率。结果观察组治疗总有效率为91.30%,明显高于对照组的73.91%(P<0.05)。治疗后,两组患者TC、LDL-C、TG及FFA水平均降低,且观察组低于对照组(P<0.05)。治疗后,两组患者FT3、FT4水平均升高,TSH水平均降低,且观察组优于对照组(P<0.05)。观察组用药期间不良事件发生率为4.35%,明显低于对照组的17.39%(P<0.05)。结论左旋甲状腺素片治疗甲减的效果显著,可有效改善患者血脂水平,且药物安全性较高,值得临床推广应用。
Objective To analyze the effect of levothyroxine tablets on blood lipid metabolism in the treatment of hypothyroidism and its safety.Methods Ninety-two patients with hypothyroidism admitted in our hospital from February 2016 to September 2017 were selected as the study objects.According to random number table method,all patients were divided into control group and observation group,with 46 cases in each group.The control group was treated with thyroxine tablets orally,while the observation group was treated with levothyroxine tablets orally,and both groups were treated for 6 months.The clinical efficacy,blood lipid level,thyroid function and incidence of adverse events were compared between the two groups.Results The total effective rate of the observation group was 91.30%,which was significantly higher than 73.91% of the control group (P<0.05).After treatment,the levels of TC,LDL-C,TG and FFA in both groups decreased,and those in the observation group were lower than the control group (P<0.05).After treatment,the levels of FT3 and FT4 increased and TSH decreased in both groups,and those of the observation group were better than the control group (P<0.05).The incidence of adverse events was 4.35% in the observation group,which was significantly lower than 17.39% in the control group (P<0.05).Conclusion Levothyroxine tablets is effective in the treatment of hypothyroidism.It can effectively reduce blood lipid levels,with high safety,which is worthy of clinical promotion and application.
作者
张红菊
秦东平
ZHANG Hong-ju;QIN Dong-ping(Pucheng County Hospital,Weinan 715500;the Traditional Chinese Medicine Hospital of Pucheng County,Weinan 715500,China)
出处
《临床医学研究与实践》
2019年第13期56-58,共3页
Clinical Research and Practice
