摘要
目的观察亚临床甲状腺功能减退症患者用左旋甲状腺激素替代治疗后临床症状和血脂的改变.方法亚临床甲状腺功能减退症患者34例,每天应用左旋甲状腺素12.5～50.0 μg治疗.观察临床症状和游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体、甲状腺球蛋白抗体(TGAb)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、载脂蛋白E(ApoE)、脂蛋白(a)水平及甲状腺B超表现.结果 34例甲状腺激素替代治疗后TSH达正常,其中29例TSH下降到正常,5例TSH偏低者其FT4轻度升高,经调整剂量后TSH、FT4均达到正常.TC、TG、LDL-C、HDL-C、脂蛋白(a)均正常.17例甲状腺肿大者均恢复.结论亚临床甲状腺功能减退症的替代治疗以小剂量左旋甲状腺素(12.5 μg)开始治疗,疗效甚好.
Objective To observe the changes of serum lipids and clinical symptoms of subclinical hypothyroidism following thyroid hormone treatment. Methods 34 subclinical hypothyroidism cases were treated with L-thyroid hormone, 12.5-50μg per day. Clinical symptoms, free thyroxine （ FF4 ） , thyroid stimulating hormone （ TSH ） , thyroid peroxidase antlbody,thyroid globulin antibody（TGAb） ,total cholesteral （TC） ,triacylglycerol （TG） ,LDL-cholesteral （ LDL-C ） ,HDL-cholesteral （ HDL-C ） , APoA1 , ApoB, ApoE,lipoprotein （a） and thyroid ultrasound findings were observed. Results TSH reached normal in 34 cases after treatment with thyroid hormone treatment. TSH and FF4 were regulated via adjusting dosage of thyroid hormone treatment to normal in 5 of 34 cases, whose TSH was much lower but Fr4 was slightly elevated before treatment. TC,TG, LDL-C and HDL-C and lipoprotein（a）level were turned to normal in all cases. Enlarged thyroid in 17 cases were all recovered. Conclusion 12.5 μg L-thyroxin as initial dosage can achieve better therapeutic effect in treating subclincial hypothyroidism.
出处
《中国综合临床》
北大核心
2005年第12期1102-1104,共3页
Clinical Medicine of China
