摘要
目的探讨腰椎间盘退变病人血清炎症因子水平变化及其临床意义。方法选取2016年3月—2017年4月在我院接受治疗的60例退变性腰椎间盘组织病变病人作为观察组,同时选取在我院体检的健康成年人60例作为对照组。比较两组研究对象血清炎症因子和基质细胞衍生因子-1(SDF-1)水平的差异,分析退变性腰椎间盘组织病变病人血清炎症因子水平与SDF-1水平的相关性。结果观察组病人血清白细胞介素-18(IL-18)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)和SDF-1水平均明显高于对照组,差异有统计学意义(t=18.492～41.235,P<0.01)。退变性腰椎间盘组织病变病人血清IL-18、IL-6、hs-CRP水平与SDF-1水平呈显著正相关(r=0.642～0.663,P<0.01)。结论腰椎间盘退变病人的血清炎症因子水平较高,且与SDF-1水平密切相关,临床检测血清炎症因子水平有助于判断腰椎间盘退变的病情严重程度和治疗效果。
Objective To investigate the changes and clinical significance of serum inflammatory factors in patients with lumbar disc degeneration. Methods A total of 60 patients with lumbar disc degeneration who were treated in our hospital from March 2016 to April 2017 were enrolled as observation group, and 60 healthy adults who underwent physical examination in our hospital were enrolled as control group. The two groups were compared in terms of serum inflammatory factors and stromal cell-derived factor-1 (SDF-1), and the correlation of serum inflammatory factors with SDF-1 was analyzed in patients with lumbar disc degeneration. Results The observation group had significantly higher serum levels of interleukin-18 (IL-18), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and SDF-1 than the control group ( t =18.492-41.235, P <0.01). In the patients with lumbar disc degeneration, the serum levels of IL-18, IL-6, and hs-CRP were positively correlated with SDF-1 level ( r = 0.642-0.663, P <0.01). Conclusion Patients with lumbar disc degeneration have high serum levels of inflammatory factors, which are positively correlated with SDF-1 level. Clinical measurement of serum inflammatory factors can help to evaluate the severity and treatment outcome of lumbar disc degeneration.
作者
黄守镔
钟浩博
孙春汉
HUANG Shoubin;ZHONG Haobo;SUN Chunhan(Orthopedics Department, Huizhou First People's Hospital, Huizhou 516000, China)
出处
《青岛大学学报（医学版）》
CAS
2019年第2期168-170,共3页
Journal of Qingdao University(Medical Sciences)
基金
湖北省自然科学基金资助项目(2016FFB04310)
