摘要
目的:探讨白细胞计数(WBC)、肿瘤坏死因子-α(TNF-α)、超敏C-反应蛋白(hs-CRP)和降钙素原(PCT)在细菌性和支原体肺炎患儿辅助鉴别中的参考价值。方法:收集2016年1月至2017年4月我院儿科收治的细菌性肺炎和支原体肺炎患儿以及同期体检的健康儿童各55例。采用全自动血细胞分析仪进行WBC计数,酶联免疫吸附法检测血清TNF-α水平,免疫散色比浊法检测hs-CRP水平,电化学发光法检测PCT水平。通过受试者工作曲线(ROC)评价WBC、TNF-α、hs-CRP和PCT单独检测以及联合检测在小儿细菌性和支原体肺炎辅助鉴别中的参考价值。结果:细菌性肺炎患儿各指标水平显著高于支原体肺炎患儿,而支原体肺炎患儿又明显高于健康儿童(P均<0.01)。联合检测的AUC(0.954)、敏感度(95.3%)和特异度(90.5%)均高于各指标单独检测(P<0.05)。结论:WBC、TNF-α、hs-CRP和PCT联合检测可为小儿细菌性和支原体肺炎的辅助鉴别提供一定参考价值。
Objective: To investigate the reference value of white blood cell count (WBC), tumor necrosis factor-α(TNF-α), high-sensitivity C-reactive protein (hs-CRP) and procalcitonin (PCT) in the differential diagnosis of children with bacterial and Mycoplasma pneumonia. Methods: Fifty-five children with bacterial and Mycoplasma pneumonia and 55 healthy children in the same period were collected from the department of pediatrics of our hospital from Jan. 2016 to Apr. 2017. WBC count was performed by automatic blood cell analyzer, serum TNF-αlevel was detected by enzyme-linked immunosorbent assay, hs-CRP level was detected by immunoturbidimetry, and PCT level was detected by electrochemiluminescence method. The reference value of WBC, TNF-α, hs-CRP,and PCT in separate detection and combined detection in differential diagnosis of pediatric bacterial and Mycoplasma pneumonia was evaluated by receiver operating curve (ROC). Results: The levels of indicators in children with bacterial pneumonia were ignificantly higher than those in children with Mycoplasma pneumonia, and the latterwere significantly higher than those in healthy children (P<0.01).The AUC (0.954), sensitivity (95.3%) and specificity (90.5%) of combined detection were higher than those of separate detection (P<0.05). Conclusion: The combined detection of WBC, TNF-α, hs-CRP and PCT can provide some reference value for the differential diagnosis of bacterial and Mycoplasma pneumonia in children.
作者
周云
陈丽蓥
冉扬
杜明洪
田芬
Zhou Yun;Chen Liying;Ran Yang;Du Minghong;Tian Fen(Fuling District Maternal and Child Health Care Hospital of Chongqing,Chongqing 408000,China)
出处
《儿科药学杂志》
CAS
2019年第3期4-6,共3页
Journal of Pediatric Pharmacy
关键词
细菌性肺炎
支原体肺炎
受试者工作曲线
辅助鉴别
bacterial pneumonia
Mycoplasma pneumonia
receiver operating curve
differential diagnosis
