摘要
目的:分析红霉素与阿奇霉素用于支原体大叶性肺炎的治疗对患儿全身炎症反应和肺功能的影响。方法:选取我院(2016年9月~2018年2月)收治的支原体大叶性肺炎患儿62例,根据治疗方法不同分为对照组和观察组。对照组患儿采用红霉素治疗,观察组患儿采用阿奇霉素治疗,分析两组患儿治疗后的临床效果。结果:观察组患儿总有效率为93.55%,对照组为70.97%,观察组患儿总有效率高于对照组,差异有统计学意义。观察组患儿发热、咳嗽及肺部阴影消失时间短于对照组,差异有统计学意义。治疗前,两组患儿炎症指标、TM、D-D水平及肺功能指标比较,差异无统计学意义。治疗后,观察组患儿IL-1β、TNF-α、INF-γ、IL-4、TM、D-D水平低于对照组,FVC、FEV1、PEF水平高于对照组,差异有统计学意义。结论:阿奇霉素治疗支原体大叶性肺炎疗效显著,可减轻患儿炎症反应,降低患儿TM、D-D水平,改善患儿肺功能。
Objective To analyze the effect of erythromycin and azithromycin on systemic inflammation and pulmonary function in children with mycoplasma lobar pneumonia.Methods From September 2016 to February 2018,62 cases of mycoplasma lobar pneumonia were selected and divided into control group and observation group according to different treatment methods.The patients in the control group were treated with erythromycin,and the children in the observation group were treated with azithromycin.Results The total effective rate was 93.55 in the observation group and 70.97 in the control group.The total effective rate in the observation group was higher than that in the control group.The time of fever,cough and pulmonary shadow disappearance in the observation group was shorter than that in the control group.Before treatment,there was no significant difference in the levels of TMN D-D and pulmonary function between the two groups.After treatment,the levels of IL-1βTNF-αTNF-αINF-γIL-4 and TMD-D in the observation group were lower than those in the control group.The levels of EV1 and PEF were higher than those in the control group.Conclusion Azithromycin was effective in the treatment of mycoplasma lobar pneumonia.
作者
蒋平
祁海啸
Jiang Ping;Qi Hai-xiao(Liyang Branch of Jiangsu Provincial People’s Hospital Pediatric Liyang,Liyang 213300,China)
出处
《晓庄学院学报（医学版）》
2019年第6期170-172,共3页
Journal of Hunan Normal University(Medical Sciences)
关键词
红霉素
阿奇霉素
支原体感染
大叶性肺炎
肺功能
炎症反应
erythromycin
azithromycin
mycoplasma infection
lobar pneumonia
pulmonary function
inflammatory reaction
