摘要
HIV-1的感染高度依赖其圆锥形的"富勒烯"型衣壳。衣壳由大约1 500个衣壳蛋白组装而成。近年来,衣壳蛋白已成为设计和筛选抗HIV-1药物的理想靶点。目前,文献已报道了多种基于不同原理的HIV-1衣壳蛋白抑制剂的筛选方法,该文将对这些体外筛选方法进行综述。
Human immunodeficiency virus type 1 (HIV-1) infection is highly dependent on its conical fullerene capsid,which is composed of approximately 1 500 capsid proteins.In recent years,capsid protein has been recognized as an ideal target for design and screening drugs for AIDS therapy.Screening methods are the key to develop HIV-1 capsid inhibitors.A variety of screening approaches for HIV-1 capsid protein inhibitor,which have been reported in the literature are reviewed in the article.
作者
张大为
许晓双
常珊
ZHANG Da-wei;XU Xiao-shuang;CHANG Shan(Institute of Bioinformatics and Medical Engineering,Jiangsu University of Technology,Changzhou Jiangsu 213001,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2019年第4期473-477,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 31700297)
2017江苏省双创计划"双创博士"
