摘要
目的探讨血管紧张素Ⅱ水平与肝硬化严重程度的相关性。方法选取122例肝硬化患者作为研究组,122名年龄、性别与其匹配的体检健康者为对照组。采用终末期肝病模型(MELD)和终末期肝病模型联合血清钠(MELD-Na)评分对患者肝硬化严重程度进行评价。检测各组血清血管紧张素Ⅱ水平并作比较。结果研究组血清血管紧张素Ⅱ水平显著高于对照组(P<0.001)。MELD≥20分组血清血管紧张素Ⅱ水平显著高于MELD<9分组和MELD 10～19分组(P<0.05)。相关分析发现,血清血管紧张素Ⅱ水平与MELD评分呈正相关(r=0.563,P<0.001),MELD-Na评分>23分组血清血管紧张素Ⅱ水平显著高于MELD-Na评分≤23分组(P<0.001)。血清血管紧张素Ⅱ水平与MELD-Na评分呈正相关(r=0.621,P<0.001),肝硬化合并腹水患者的血管紧张素Ⅱ水平显著高于肝硬化未合并腹水的患者(P<0.001)。结论肝硬化患者血管紧张素Ⅱ水平显著升高,并与肝硬化的严重程度密切相关。
Objective To investigate the correlation between angiotensinⅡlevel and the severity of liver cirrhosis.Methods A total of 122 patients with liver cirrhosis were enrolled as study group,and 122 healthy subjects matched with age and sex were enrolled as control group.The end-stage liver disease model(MELD)and end-stage liver disease model combined with serum sodium(MELD-Na)scores were used to assess the severity of liver cirrhosis.Serum angiotensinⅡlevels of the 2 groups were determined.Results Serum angiotensinⅡlevel in study group was higher than that in control group(P<0.001).Serum angiotensinⅡlevel in MELD≥20group was higher than those in MELD<9group and MELD10-19group(P<0.05).Correlation analysis showed that there was a positive correlation between serum angiotensinⅡlevel and MELD score(r=0.563,P<0.001).Serum angiotensinⅡlevel with MELD-Na>23group was higher than that with MELD-Na≤23group(P<0.01).There was a positive correlation between serum angiotensinⅡlevel and MELD-Na score(r=0.621,P<0.001).Serum angiotensinⅡlevel in liver cirrhosis patients with ascites was higher than that in liver cirrhosis patients without ascites(P<0.001).Conclusions In patients with liver cirrhosis,serum angiotensinⅡlevel is increased and is closely related to the severity of liver cirrhosis.
作者
康海岩
郝若飞
任赐菊
KANG Haiyan;HAO Ruofei;REN Ciju(Department of Nuclear Medicine,the Affiliated Hospital of Qinghai University,Xining810001,Oinghai,China;Huguosi Hospital of Traditional Chinese Medicine,Beijing 10032,China;Department of Pain,the Affiliated Hospital of Qinghai University,Xining 810001,Qinghai,China)
出处
《检验医学》
CAS
2018年第12期1112-1115,共4页
Laboratory Medicine
关键词
血管紧张素Ⅱ
肝硬化
终末期肝病模型
终末期肝病模型联合血清钠
腹水
Angiotensin Ⅱ
Liver cirrhosis
End-stage liver disease model
End-stage liver disease model combined with serum sodium
Ascites
