摘要
目的:探讨清开灵滴丸治疗慢性咽炎的疗效及对血清表皮生长因子(EGF)、白介素-1β(IL-1β)、血管内皮细胞粘附分子-1(VCAM-1)的影响。方法:选择2015年10月至2017年10月我院接诊的120例慢性咽炎患者作为本研究对象,通过简单随机数表法分为观察组62例和对照组58例,对照组给予常规地塞米松磷酸钠+庆大霉素雾化治疗,观察组在对照组基础上,联合清开灵滴丸治疗,两组均以1周为1个疗程,连续治疗3个疗程。比较两组临床疗效、血清炎症因子和EGF、IL-1β、VCAM-1变化,并比较不良反应和3个月复发率。结果:治疗后,观察组临床疗效总有效率为93.55%(58/62),明显高于对照组的79.31%(46/58)(P<0.05);治疗后,两组血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、白介素-6(IL-6)较治疗前均得到显著降低(P<0.05),且观察组血清TNF-α、CPR、IL-6均明显比对照组低[(94.52±13.89) ng/L vs(21.37±17.43) ng/L,(13.42±1.68) mg/L vs(22.30±2.93) mg/L,(110.27±14.19) ng/L vs(158.33±19.34) ng/L](P <0.05);治疗后,两组血清IL-1β较治疗前均显著降低,血清EGF、VCAM-1显著升高(P<0.05),观察组IL-1β明显低于对照组,EGF、VCAM-1明显比对照组高[(82.37±8.90) pg/m L vs(114.06±12.17) pg/m L,(4.42±0.72)μg/L vs(3.37±0.68)μg/L,(8.19±1.40) ng/m L vs(5.68±1.06) ng/m L](P <0.05);治疗期间,观察组和对照组不良反应总发生率分别为9.68%(6/62)和8.62%(5/58),差异无统计学意义(P>0.05);通过随访3个月随访结果显示,观察组治愈患者中有2例复发,复发率为5.26%(2/38),对照组有7例复发,复发率为25.00%(7/28),观察组复发率明显低于对照组(P<0.05)。结论:在慢性咽炎患者中使用清开灵滴丸效果显著,可有效促进疾病恢复,短期内复发率低,其内在机制可能和调节血清EGF、IL-1β、VCAM-1的表达相关,且安全性高,值得应用推广。
Objective:To study curative efficacy of Qingkailing dripping pills in treatment of chronic pharyngitis and effects on serum epidermal growth factor(EGF),interleukin-1β(IL-1β)and Vascular endothelial cell adhesion molecule-1(VCAM-1)levels.Methods:120 patients of chronic pharyngitis admitted to our hospital from October 2015 to October 2017 were selected as research objects,according to the simple random number table,those patients were divided into the 62 cases of observation group and the 58 cases control group,the control group was treated with conventional dexamethasone sodium phosphate+gentamicin atomization treatment,and the observation group was treated with Qingkailing dripping pills on the basis of the control group.They were treated with 1 weeks for 1 courses,and 3 consecutive courses of treatment.The clinical efficacy,the changes of serum inflammatory factors,EGF,IL-1βand VCAM-1 were compared between the two groups,and the adverse reactions and the 3 months recurrence rate were compared.Results:After treatment,the total effective rate of the observation group was 93.55%(58/62),which was significantly higher than that of the control group 79.31%(46/58)(P<0.05);after treatment,the serum tumor necrosis factor-α(TNF-α),C reactive protein(CRP)and interleukin-6(IL-6)in the two groups were significantly lower than those before the treatment(P<0.05),and the serum-α,CPR and IL-6 in the observation group were significantly lower in the observation group than that of the control group[(94.52±13.89)ng/L vs(21.37±17.43)ng/L,(13.42±1.68)mg/L vs(22.30±2.93)mg/L,(110.27±14.19)ng/L vs(158.33±19.34)ng/L](P<0.05).After treatment,the serum IL-1βin the two groups were significantly lower than those before the treatment,and the serum EGF and VCAM-1 was significantly higher(P<0.05),and the IL-1βin the observation group were significantly lower than that of the control group,and the EGF and VCAM-1 was significantly higher than that of the control group[(82.37±8.90)pg/ml vs(114.06±12.17)pg/ml,(4.42±0.72)μg/L vs(3.37±0.68)μg/L,(8.19±1.40)ng/ml vs(5.68±1.06)ng/ml](P<0.05).During the treatment period,the incidence of adverse reactions in the observation group and the control group was 9.68%(6/62)and 8.62%(5/58)respectively,and the difference was not statistically significant(P>0.05).The follow-up results of 3 months follow-up showed that 2 cases relapsed in the observation group,the recurrence rate was 5.26%(2/38),and 7 cases relapsed iin the control group,the recurrence rate was 25%(7/28),and the recurrence rate of the observation group was significantly lower than that of the control group(P<0.05).Conclusion:Qingkailingdi pills is well for chronic pharyngitis,which can effectively promote the recovery of the disease,and the recurrence rate is low in the short term.It's internal mechanism may be related to the regulation of the expression of serum EGF,IL-1βand VCAM-1,and it's highly safe and worthy of application.
作者
吴祥基
苏炳泽
吴李仲
王正和
苏明昌
WU Xiangji(Qionghai People's Hospital,Hainan Qionghai 571400,China)
出处
《河北医学》
CAS
2018年第12期1960-1965,共6页
Hebei Medicine
基金
海南省自然科学基金
(编号:811207)
关键词
慢性咽炎
清开灵滴丸
表皮生长因子
白介素-1Β
血管内皮细胞粘附分子-1
Chronic pharyngitis
Qingkailingdi pills
Epidermal growth factor
Interleukin-1β
Vascular endothelial cell adhesion molecule-1
