摘要
目的比较血凝酶与氨甲环酸对颅脑外伤手术患者止血效果。方法颅脑外伤手术患者100例,随机分为A组和B组,每组50例。A组于手术开始至术毕给予氨甲环酸注射液0.25 g加入0.9%氯化钠注射液250 m L静脉滴注;B组于术前30 min给予血凝酶1 U加入0.9%氯化钠注射液10 m L肌内注射,手术开始至术毕给予血凝酶1 U加入0.9%氯化钠注射液250 m L静脉滴注。结果 A组和B组术中出血量分别为(968.02±102.96),(726.97±81.42)m L,输血量分别为(735.12±74.24),(575.72±60.67)m L,术后24 h引流量分别为(182.45±23.54),(150.22±18.47)m L,再出血率分别为16.00%,2.00%(均P<0.05);B组格拉斯哥预后评分预后良好率(60.00%)明显高于A组(40.00%)(P<0.05);两组术前术后凝血酶原时间、部分凝血活酶时间和不良反应发生率基本相同,且均无血栓性疾病发生(P>0.05)。结论与氨甲环酸比较,血凝酶对颅脑外伤手术患者止血效果较好,有利于避免术后再出血及改善预后。
Objective To compare the hemostatic effect of hemocoagulase vs.tranexamic acid in patients with craniocerebral trauma surgery.Methods In total,100 patients with craniocerebral trauma surgery were randomly divided into group A and group B(50 cases in each group).Group A was intravenously injected with tranexamic acid injection 0.25g+0.9%sodium chloride solution 250 mL from operation beginning to operation ending.Group B was intramuscularly injected with hemocoagulase 1U+0.9%sodium chloride solution 10 mL 30 min before the surgery,and intravenously injected with hemocoagulase 1 U+0.9%sodium chloride solution 250 mL from operation beginning to operation ending.Results The intraoperatve blood loss of group A and group B was(968.02±102.96),(726.97±81.42)mL,blood transfusion volume(735.12±74.24),(575.72±60.67)mL,drainage 24 h after the operation was(182.45±23.54),(150.22±18.47)mL.Re-bleeding rate was 16.00%and 2.00%(all P<0.05).According to the Glasgow Prognosis Score,good prognosis rate of group B(60.00%)was significantly higher than that of group A(40.00%)(P<0.05).The preoperative and postoperative prothrombin time(PT),activated partial thromboplastin time(APTT)and adverse reaction rates of the two groups were almost the same,and there was no thrombosis disease(P>0.05).Conclusion Compared with tranexamic acid,the hemostatic effect of hemocoagulase is better in patients with craniocerebral trauma operations,and it is helpful to avoid postoperative re-bleeding and improve the prognosis of patients.
作者
吴志明
WU Zhiming(Department of Neurosurgery,the People's Hospital of the Linshui County,Guang'an City,Sichuan Province,Guang'an 638500,China)
出处
《医药导报》
CAS
北大核心
2018年第9期1086-1089,共4页
Herald of Medicine
关键词
血凝酶
氨甲环酸
手术
颅脑外伤
止血效果
Hemocoagulase
Tranexamic acid
Operation,craniocerebral trauma
Hemostatic effect
