摘要
目的观察不同液体复苏方式对创伤性失血性休克大鼠的影响。方法制备创伤未控制失血性休克SD大鼠模型80只,随机分为4组,每组20只。A组为对照组;B组为失血性休克但无液体复苏组;C组为限制性液体复苏组;D组为非限制性液体复苏组。比较4组大鼠液体复苏后2 h的死亡率、生理指标与实验室指标。结果 A组大鼠死亡率均低于B组、C组及D组,C组死亡率低于B组及D组(均P<0.05),液体复苏结束2 h后,4组大鼠体重、Hb、红细胞比容(Hct)及PLT水平比较,差异均无统计学意义(均P>0.05),4组大鼠MAP水平由高至低依次为A组>D组>C组>B组(均P<0.05);B组休克指数及Lac水平均高于A组、D组与C组(P<0.05),D组休克指数及Lac水平高于A组与C组(均P<0.05),而C组休克指数及Lac水平与A组比较,差异均无统计学意义(均P>0.05);B组血p H水平均低于A组、C组及D组(均P<0.05),而A组、C组及D组血p H水平比较,差异无统计学意义(P>0.05)。结论与非限制性液体复苏相比,限制性液体复苏可降低创伤性失血性休克大鼠死亡率及休克指数,同时能维持组织灌注需要的基本MAP,可有助于改善大鼠预后。
Objective To observe the effects of different resuscitation methods on traumatic and hemorrhagic shock in rats.Methods The 80 SD rat models of uncontrolled traumatic and hemorrhagic shock were developed,which were randomly divided into four groups,with 20 rats in each group.Group A was defined as control group;the rats in group B suffered hemorrhagic shock but without fluid resuscitation;the rats in group C accepted restrictive crystalloid resuscitation;and the rats in group D accepted non-restrictive fluid resuscitation.The mortality and the physiological and laboratory indexes were compared among the four groups after two hours of fluid resuscitation.Results The mortality of group A was lower than that of group B,C or D,and the mortality of group C was lower than that of group B or D(all P<0.05).After two hours of fluid resuscitation,no significant difference was found in the body weight,Hb,Hct or PLT level among the four groups(all P>0.05),the levels of rat mean arterial pressure(MAP)of group A,group D,group C and group B decreased in turn(all P<0.05);the shock index and the blood lactic acid(Lac)level of group B were higher than those of group A,B or C(P<0.05),the shock index and the Lac level of group D were higher than those of group A or C(all P<0.05),there was no significant difference in the shock index or Lac level between group C and group A(all P>0.05);the level of blood pH of group B was lower than that of group A,C or D(all P<0.05),but there was no statistically significant difference in the level of blood pH among group A,group C and group D(P>0.05).Conclusion Compared to non-restrictive fluid resuscitation,restrictive fluid resuscitation can reduce the mortality and shock index of rats with traumatic and hemorrhagic shock as well as maintain the basic MAP demands for tissue perfusion,which is conductive to improving the prognosis of rats.
作者
李柱伟
马英淇
马宏飞
李霞
张晶晶
肖开提.依不拉音
LI Zhu-wei;MA Ying-qi;MA Hong-fei;LI Xia;ZHANG Jing-jing;Xiaokaiti Yibulayin(Center for Trauma Emergency,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Oncology,the Second Hospital of Dalian Medical University,Dalian 116027,China;Department of Nuclear Medicine,the Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830000,China)
出处
《广西医学》
CAS
2018年第6期662-664,669,共4页
Guangxi Medical Journal
基金
新疆维吾尔自治区自然科学基金(2015211C073)
关键词
创伤性失血性休克
大鼠
限制性液体复苏
预后
Traumatic and hemorrhagic shock
Rat
Restrictive fluid resuscitation
Prognosis
