摘要
目的研究冠心病患者阿司匹林抵抗的危险因素。方法回顾性分析我院2012年1月~2017年4月收治的冠心病患者的临床资料,按纳入与排除标准分别筛选发生阿司匹林抵抗(AR组)与未发生AR患者(NAR组)各40例,比较两组患者的一般临床资料及相关实验室指标,分析冠心病患者发生AR的危险因素。结果 AR组的视黄醇结合蛋白(RBP)水平低于NAR组,肌酐(SCr)、Hcy、CD62P水平高于NAR组,差异有统计学意义(P<0.05)。以是否发生AR为自变量,Hcy、CD62P均为冠心病患者发生AR的危险因素,以Hcy危险值最高。结论 Hcy、CD62P均为冠心病患者发生AR的危险因素,或可成为预估冠心病患者发生AR风险的有效指标。
Objective To study the risk factors of aspirin resistance in patients with coronary heart disease(CHD).Methods The clinical data of patients with CHD admitted into our hospital from January 2012 to April 2017 were retrospectively analyzed.According to inclusion and exclusion criteria,40 patients with aspirin resistance(AR group)or without AR(NAR group)were screened respectively.The general clinical data and the related laboratory indexes were compared between the two groups,and the risk factors of AR in patients with CHD were analyzed.Results The level of retinol-binding protein(RBP)in the AR group was lower than that in the NAR group while the level of creatinine(SCr),Hcy and CD62P were higher than those in the NAR group(P<0.05).Taken AR as the dependent variable,the Hcy and CD62P were risk factors for AR in patients with CHD,and the risk value of Hcy was highest.Conclusion Hcy and CD62P are the risk factors for AR in patients with CHD,or it can be an effective index in the predicting the AR risk in patients with CHD.
作者
周立尧
郭建浩
李剑平
陈若峰
王佳
ZHOU Li-yao;GUO Jian-hao;LI Jian-ping;CHEN Ruo-feng;WANG Jia(Department of Cardiovascular Medicine,Beijiao Hospital of Shunde District in Foshan City,Guangdong Province,Foshan 528311,China)
出处
《中国当代医药》
2018年第10期56-58,共3页
China Modern Medicine
关键词
阿司匹林抵抗
冠心病
危险因素
Aspirin resistance
Coronary heart disease
Risk factors
