摘要
【目的】探讨冠心病患者体脂分布与血脂代谢的相关性。【方法】选取2015年6月至2017年6月于秦皇岛市第一医院体检中心进行常规体检的健康人群(对照组,n=80)及冠心病患者(观察组,n=70)。应用双能X线骨密度测定仪(DEXA)对受试者进行体脂分析,比较两组总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿酸(UA)水平,并分析冠心病组体脂分布特点及其与血脂代谢的相关性。【结果】两组年龄、BMI比较,差异无统计学意义(P>0.05);观察组血清TG、TC、LDL-C、UA水平高于对照组,差异具有统计学意义(P<0.05),但血清HDL-C水平比较,差异无统计学意义(P>0.05)。观察组身高、体质量与对照组比较,差异无统计学意义(P>0.05);观察组腰围、SBP、DBP显著高于对照组,差异具有统计学意义(P<0.05)。观察组脂肪质量显著高于对照组,肌肉质量、BMC、BMD显著低于对照组,差异均具有统计学(P<0.05)。BMD、BMC与总体肌肉质量、总体脂肪质量、TG、TC、LDL-C呈正相关(P<0.05)。【结论】冠心病与脂肪质量、肌肉质量、BMC、BMD具有显著相关性,提示体成分分布、血脂异常在冠心病发生、发展中扮演着重要角色。
[Objective]To explore the correlation between body fat distribution and blood lipid metabolism in patients with coronary heart disease.[Methods]A total of 70 coronary,heart disease patients (the observa- tion group)and 80 healthy volunteers (the control group )from June 2015 to June 2017 were enrolled in this study.Body fat composition and bone mineral density (BMD)were measured by dual-energy X-ray absorpti- ometry (DEXA).The levels of total cholesterol (TC),triglyceride (TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C)and uric acid (UA)were compared between the two groups.The correlation between body fat distribution and lipid metabolism was analyzed in the coronary heart disease group.[Results]There was no significant difference in age and BMI between the observation group and the control group (P >0.05).The levels of serum TG,TC,LDL-C and UA in the observation group were significantly higher than those in the control group (P <0.05),but the serum HDL-C levels were not signifi- cantly different (P >0.05).There was no significant difference in height and body weight between the observation group and the control group (P>0.05).The waist circumference,SBP and DBP in the observation group were significantly higher than the control group (P <0.05).The fat mass of the observation group was significantly higher than that of the control group,while the muscle mass,BMC and BMD were significantly lower than those of the control group (P <0.05).BMD and BMC were positively correlated with overall muscle mass,total fat mass,TG,TC and LDL-C (P<0.05).[Conclusion]Coronary heart disease has significant regression with fat mass,muscle mass,BMC and BMD,suggesting that body composition distribution and dyslipidemia play an important role in the occurrence and development of coronary heart disease.
作者
焦巳彧
崔玉杰
纪美晶
蒋韬
毛曼
李群
陆强
JIAO Si-yu;CUI Yu-jie;JI Mei-jing(The First Hospital of Qinhuan gdao ,Qinhuan gdao ,Hebei Province ,066000,China)
出处
《医学临床研究》
CAS
2018年第11期2101-2103,共3页
Journal of Clinical Research
基金
秦皇岛市科学技术研究与发展计划项目(201503A139)。
