摘要
目的:分析大剂量丙种球蛋白冲击治疗在腹型过敏性紫癜中的应用疗效以及不良反应。方法:选取我院2014年1月~2016年12月收治的腹型过敏性紫癜患儿118例,随机分为常规组与研究组各59例。常规组予以常规治疗,研究组在常规治疗基础上加用大剂量丙种球蛋白冲击治疗,比较两组的治疗效果、症状缓解时间、不良反应。结果:(1)研究组有效率为98.31%,高于常规组的86.44%,组间差异显著(P<0.05);(2)研究组的症状(呕吐、血便、腹痛、皮疹、关节症状)缓解时间短于常规组(P<0.05);(3)研究组肉眼血尿(3.39%)、恶心呕吐(3.39%)、发热(1.69%)、泡沫尿(1.69%)发生率与常规组接近,组间差异无统计学意义(P>0.05)。结论:腹型过敏性紫癜采用大剂量丙种球蛋白冲击治疗,可促进症状尽早缓解,提升疗效,不影响不良反应率,值得临床推广。
Objective:To analyze the curative effects and adverse reactions of pulse therapy with large dose of gamma globulin in the treatment of abdominal allergic purpura.Methods:From Jan.2014 to Dec.2016,a total of 118 children with abdominal allergic purpura in our hospital were taken as the clinical objects,and they were randomly divided into study group(59 cases)and control group(59 cases).Both groups were given routine treatment,besides,the study group was given large dose of gamma globulin.The curative effects,symptom remission time and adverse reactions in the two groups were compared.Results:The effective rate in the study group was 98.31%which was obviously higher than that in the control group 86.44%,and their difference was statistically significant(P约0.05).The symptom(vomiting,bloody stool,abdominal pain,rash,joint symptom)remission time in the study group was significantly shorter than that in the control group(P约0.05).The incidence rates of gross hematuria,nausea and vomiting,fever and foam urine in the study group were respectively 3.39%,3.39%,1.69%and 1.69%which were close to those in the control group,and their differences were not statistically significant(P跃0.05).Conclusion:Large dose of gamma globulin which has less adverse reactions in the treatment of abdominal allergic purpura,can alleviate symptoms as soon as possible and improve curative effects.Thus,it is worthy of application in clinic.
作者
牛文静
Niu Wenjing(Department of pediatrics,The Second People's Hospital of Xinxiang,Xinxiang 453000,Henan province,China)
出处
《北方药学》
2018年第4期8-9,共2页
Journal of North Pharmacy
关键词
腹型过敏性紫癜
丙种球蛋白
不良反应
冲击治疗
Abdominal allergic purpura
Gamma globulin
Adverse reaction
Pulse therapy
